Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 1998103..1998891 | Replicon | chromosome |
| Accession | NZ_CP022899 | ||
| Organism | Staphylococcus aureus strain 143 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | CGP95_RS10130 | Protein ID | WP_000525012.1 |
| Coordinates | 1998430..1998891 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | CGP95_RS10125 | Protein ID | WP_000333630.1 |
| Coordinates | 1998103..1998417 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CGP95_RS10070 | 1993339..1993890 | - | 552 | WP_000704705.1 | single-stranded DNA-binding protein | - |
| CGP95_RS10075 | 1993919..1994707 | - | 789 | WP_000134097.1 | ATP-binding protein | - |
| CGP95_RS10080 | 1994700..1994921 | - | 222 | WP_000815402.1 | DUF2483 family protein | - |
| CGP95_RS10085 | 1994931..1995191 | - | 261 | WP_000291089.1 | DUF1108 family protein | - |
| CGP95_RS10090 | 1995287..1995448 | - | 162 | WP_000066011.1 | DUF1270 domain-containing protein | - |
| CGP95_RS10095 | 1995441..1995662 | - | 222 | WP_000594789.1 | hypothetical protein | - |
| CGP95_RS10100 | 1995733..1995963 | + | 231 | WP_000395455.1 | hypothetical protein | - |
| CGP95_RS10105 | 1996139..1996879 | - | 741 | WP_001148585.1 | phage antirepressor KilAC domain-containing protein | - |
| CGP95_RS10110 | 1996939..1997421 | + | 483 | WP_000394410.1 | hypothetical protein | - |
| CGP95_RS10115 | 1997522..1997701 | - | 180 | WP_000438352.1 | hypothetical protein | - |
| CGP95_RS10120 | 1997715..1997951 | - | 237 | WP_001121116.1 | helix-turn-helix domain-containing protein | - |
| CGP95_RS10125 | 1998103..1998417 | + | 315 | WP_000333630.1 | helix-turn-helix domain-containing protein | Antitoxin |
| CGP95_RS10130 | 1998430..1998891 | + | 462 | WP_000525012.1 | hypothetical protein | Toxin |
| CGP95_RS10135 | 1998912..1999403 | + | 492 | WP_001077638.1 | hypothetical protein | - |
| CGP95_RS10140 | 1999529..1999708 | - | 180 | WP_000337827.1 | hypothetical protein | - |
| CGP95_RS10145 | 1999821..2000867 | + | 1047 | WP_001145721.1 | site-specific integrase | - |
| CGP95_RS10150 | 2000912..2002057 | + | 1146 | WP_001245443.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| CGP95_RS10155 | 2002317..2002847 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1961497..2000867 | 39370 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 17963.27 Da Isoelectric Point: 4.5941
>T79964 WP_000525012.1 NZ_CP022899:1998430-1998891 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDAEKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFTSAVPIREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDAEKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFTSAVPIREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T79964 NZ_CP022899:1998430-1998891 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATCTAATTTTAATAAAGCGTGGTTTATCAGATGCAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCTGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTATGCACGT
AGACATGGTTTTACTTCAGCTGTACCGATACGTGAAATTGTAGAAGCTTACAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTGGAGGCAATAGAACAATATAAGAAGATATACGGTATTGGAACTC
ACTATGGCGAGTATTCGATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAAGAAATATGA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATCTAATTTTAATAAAGCGTGGTTTATCAGATGCAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCTGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTATGCACGT
AGACATGGTTTTACTTCAGCTGTACCGATACGTGAAATTGTAGAAGCTTACAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTGGAGGCAATAGAACAATATAAGAAGATATACGGTATTGGAACTC
ACTATGGCGAGTATTCGATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAAGAAATATGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT79964 WP_000333630.1 NZ_CP022899:1998103-1998417 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT79964 NZ_CP022899:1998103-1998417 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGAGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGAGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|