Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 856460..856937 Replicon chromosome
Accession NZ_CP022899
Organism Staphylococcus aureus strain 143

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CGP95_RS04200 Protein ID WP_000052076.1
Coordinates 856460..856648 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGP95_RS04205 Protein ID WP_001059690.1
Coordinates 856677..856937 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP95_RS04170 852413..852970 + 558 WP_000824491.1 hypothetical protein -
CGP95_RS04175 853311..853997 + 687 WP_001574556.1 thermonuclease family protein -
CGP95_RS04180 854354..854554 + 201 WP_001059082.1 cold-shock protein -
CGP95_RS04185 855051..855269 - 219 WP_000005879.1 hypothetical protein -
CGP95_RS04190 855331..855615 - 285 WP_001004401.1 hypothetical protein -
CGP95_RS04195 855703..856272 - 570 WP_001106663.1 hypothetical protein -
CGP95_RS04200 856460..856648 - 189 WP_000052076.1 hypothetical protein Toxin
CGP95_RS04205 856677..856937 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGP95_RS04210 857278..857481 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGP95_RS04215 857478..857714 - 237 WP_000368687.1 hypothetical protein -
CGP95_RS04220 857939..858520 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CGP95_RS04225 858593..859210 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
CGP95_RS04230 859366..859860 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CGP95_RS04235 860259..860681 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
CGP95_RS04240 860829..861545 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-48)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T79956 WP_000052076.1 NZ_CP022899:c856648-856460 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T79956 NZ_CP022899:c856648-856460 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT79956 WP_001059690.1 NZ_CP022899:c856937-856677 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT79956 NZ_CP022899:c856937-856677 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References