Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2155552..2156066 Replicon chromosome
Accession NZ_CP022898
Organism Staphylococcus aureus strain 422

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag CGP94_RS11155 Protein ID WP_000581792.1
Coordinates 2155552..2155761 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag CGP94_RS11160 Protein ID WP_000138932.1
Coordinates 2155773..2156066 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP94_RS11135 2151060..2152418 - 1359 WP_047213666.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
CGP94_RS11140 2152433..2153503 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
CGP94_RS11145 2153821..2155023 + 1203 WP_070867581.1 rod shape-determining protein RodA -
CGP94_RS11150 2155287..2155424 - 138 WP_000828354.1 hypothetical protein -
CGP94_RS11155 2155552..2155761 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
CGP94_RS11160 2155773..2156066 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
CGP94_RS11165 2156232..2157716 + 1485 WP_000571551.1 cardiolipin synthase -
CGP94_RS11170 2157744..2158391 + 648 WP_001187620.1 HD domain-containing protein -
CGP94_RS11185 2159022..2159894 - 873 WP_000725802.1 membrane protein insertase YidC -
CGP94_RS11190 2159980..2160622 - 643 Protein_2057 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T79949 WP_000581792.1 NZ_CP022898:c2155761-2155552 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T79949 NZ_CP022898:c2155761-2155552 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACGCCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT79949 WP_000138932.1 NZ_CP022898:c2156066-2155773 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT79949 NZ_CP022898:c2156066-2155773 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAAGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References