Detailed information of TA system TA079948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2135808..2136337
• Replicon: chromosome
• Accession: NZ_CP022898
• Organism: Staphylococcus aureus strain 422

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: CGP94_RS11065
• Protein ID: WP_000621175.1
• Coordinates: 2135808..2136170 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: CGP94_RS11070
• Protein ID: WP_000948331.1
• Coordinates: 2136167..2136337 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP94_RS11040	2132787..2133557	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
CGP94_RS11045	2133532..2134011	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
CGP94_RS11050	2134013..2134339	-	327	WP_001052491.1	anti-sigma factor antagonist	-
CGP94_RS11055	2134458..2135459	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
CGP94_RS11065	2135808..2136170	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CGP94_RS11070	2136167..2136337	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
CGP94_RS11075	2136422..2137570	-	1149	WP_001281143.1	alanine racemase	-
CGP94_RS11080	2137636..2137995	-	360	WP_000581198.1	holo-ACP synthase	-
CGP94_RS11085	2137999..2138490	-	492	WP_001205919.1	PH domain-containing protein	-
CGP94_RS11090	2138477..2140060	-	1584	WP_001294640.1	PH domain-containing protein	-
CGP94_RS11095	2140053..2140532	-	480	WP_001287075.1	hypothetical protein	-
CGP94_RS11100	2140741..2141301	-	561	WP_001092403.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T79948 WP_000621175.1 NZ_CP022898:c2136170-2135808 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T79948 NZ_CP022898:c2136170-2135808 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGATTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT79948 WP_000948331.1 NZ_CP022898:c2136337-2136167 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT79948 NZ_CP022898:c2136337-2136167 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCTATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1