Detailed information of TA system TA079936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2155553..2156067
• Replicon: chromosome
• Accession: NZ_CP022897
• Organism: Staphylococcus aureus strain 128

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: T1YA99
• Locus tag: CGP93_RS11155
• Protein ID: WP_000581792.1
• Coordinates: 2155553..2155762 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: W8UW13
• Locus tag: CGP93_RS11160
• Protein ID: WP_000138932.1
• Coordinates: 2155774..2156067 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP93_RS11135	2151061..2152419	-	1359	WP_047213666.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
CGP93_RS11140	2152434..2153504	-	1071	WP_000159631.1	D-alanine--D-alanine ligase	-
CGP93_RS11145	2153822..2155024	+	1203	WP_070867581.1	rod shape-determining protein RodA	-
CGP93_RS11150	2155288..2155425	-	138	WP_000828354.1	hypothetical protein	-
CGP93_RS11155	2155553..2155762	-	210	WP_000581792.1	heavy-metal-associated domain-containing protein	Toxin
CGP93_RS11160	2155774..2156067	-	294	WP_000138932.1	copper-sensing transcriptional repressor CsoR	Antitoxin
CGP93_RS11165	2156233..2157717	+	1485	WP_000571551.1	cardiolipin synthase	-
CGP93_RS11170	2157745..2158392	+	648	WP_001187620.1	HD domain-containing protein	-
CGP93_RS11185	2159023..2159895	-	873	WP_000725802.1	membrane protein insertase YidC	-
CGP93_RS11190	2159981..2160622	-	642	WP_000483160.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7843.77 Da
• Isoelectric Point: 4.1008

>T79936 WP_000581792.1 NZ_CP022897:c2155762-2155553 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T79936 NZ_CP022897:c2155762-2155553 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACGCCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11197.82 Da
• Isoelectric Point: 6.2243

>AT79936 WP_000138932.1 NZ_CP022897:c2156067-2155774 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT79936 NZ_CP022897:c2156067-2155774 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAAGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Toxin

• PDB: 6FF1

Antitoxin

• AlphaFold DB: W8UW13