79930

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 804095..804572 Replicon chromosome
Accession NZ_CP022897
Organism Staphylococcus aureus strain 128

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CGP93_RS03930 Protein ID WP_000052076.1
Coordinates 804095..804283 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGP93_RS03935 Protein ID WP_001059690.1
Coordinates 804312..804572 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP93_RS03900 800143..800625 + 483 WP_000824492.1 hypothetical protein -
CGP93_RS03905 800966..801652 + 687 WP_000141556.1 thermonuclease family protein -
CGP93_RS03910 802009..802209 + 201 WP_001059082.1 cold-shock protein -
CGP93_RS03915 802706..802924 - 219 WP_115385523.1 hypothetical protein -
CGP93_RS03920 802986..803270 - 285 WP_001004397.1 hypothetical protein -
CGP93_RS03925 803358..803906 - 549 WP_115385524.1 hypothetical protein -
CGP93_RS03930 804095..804283 - 189 WP_000052076.1 hypothetical protein Toxin
CGP93_RS03935 804312..804572 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGP93_RS03940 804913..805116 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGP93_RS03945 805113..805349 - 237 WP_000368687.1 hypothetical protein -
CGP93_RS03950 805574..806155 + 582 WP_001140691.1 phosphoglycerate mutase family protein -
CGP93_RS03955 806228..806845 - 618 WP_047213256.1 LysE/ArgO family amino acid transporter -
CGP93_RS03960 807002..807496 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
CGP93_RS03965 807895..808317 - 423 WP_031927537.1 organic hydroperoxide resistance protein -
CGP93_RS03970 808465..809181 + 717 WP_031927536.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T79930 WP_000052076.1 NZ_CP022897:c804283-804095 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T79930 NZ_CP022897:c804283-804095 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT79930 WP_001059690.1 NZ_CP022897:c804572-804312 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT79930 NZ_CP022897:c804572-804312 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References