Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 849010..849487 Replicon chromosome
Accession NZ_CP022896
Organism Staphylococcus aureus strain 277

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CGP92_RS04195 Protein ID WP_000052076.1
Coordinates 849010..849198 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGP92_RS04200 Protein ID WP_001059690.1
Coordinates 849227..849487 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP92_RS04165 844963..845520 + 558 WP_000824491.1 hypothetical protein -
CGP92_RS04170 845861..846547 + 687 WP_001574556.1 thermonuclease family protein -
CGP92_RS04175 846904..847104 + 201 WP_001059082.1 cold-shock protein -
CGP92_RS04180 847601..847819 - 219 WP_000005879.1 hypothetical protein -
CGP92_RS04185 847881..848165 - 285 WP_001004401.1 hypothetical protein -
CGP92_RS04190 848253..848822 - 570 WP_001106663.1 hypothetical protein -
CGP92_RS04195 849010..849198 - 189 WP_000052076.1 hypothetical protein Toxin
CGP92_RS04200 849227..849487 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGP92_RS04205 849828..850031 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGP92_RS04210 850028..850264 - 237 WP_000368687.1 hypothetical protein -
CGP92_RS04215 850489..851070 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CGP92_RS04220 851143..851760 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
CGP92_RS04225 851916..852410 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CGP92_RS04230 852809..853231 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
CGP92_RS04235 853379..854095 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T79914 WP_000052076.1 NZ_CP022896:c849198-849010 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T79914 NZ_CP022896:c849198-849010 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT79914 WP_001059690.1 NZ_CP022896:c849487-849227 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT79914 NZ_CP022896:c849487-849227 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References