Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 850016..850493 Replicon chromosome
Accession NZ_CP022895
Organism Staphylococcus aureus strain 85

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CGP91_RS04200 Protein ID WP_000052076.1
Coordinates 850016..850204 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGP91_RS04205 Protein ID WP_001059690.1
Coordinates 850233..850493 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP91_RS04170 845969..846526 + 558 WP_000824491.1 hypothetical protein -
CGP91_RS04175 846867..847553 + 687 WP_001574556.1 thermonuclease family protein -
CGP91_RS04180 847910..848110 + 201 WP_001059082.1 cold-shock protein -
CGP91_RS04185 848607..848825 - 219 WP_000005879.1 hypothetical protein -
CGP91_RS04190 848887..849171 - 285 WP_001004401.1 hypothetical protein -
CGP91_RS04195 849259..849828 - 570 WP_001106663.1 hypothetical protein -
CGP91_RS04200 850016..850204 - 189 WP_000052076.1 hypothetical protein Toxin
CGP91_RS04205 850233..850493 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGP91_RS04210 850834..851037 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGP91_RS04215 851034..851270 - 237 WP_000368687.1 hypothetical protein -
CGP91_RS04220 851495..852076 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CGP91_RS04225 852149..852766 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
CGP91_RS04230 852922..853416 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CGP91_RS04235 853815..854237 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
CGP91_RS04240 854385..855101 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T79898 WP_000052076.1 NZ_CP022895:c850204-850016 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T79898 NZ_CP022895:c850204-850016 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT79898 WP_001059690.1 NZ_CP022895:c850493-850233 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT79898 NZ_CP022895:c850493-850233 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References