Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1979666..1980466 Replicon chromosome
Accession NZ_CP022894
Organism Staphylococcus aureus strain 191

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag CGP90_RS10365 Protein ID WP_000525007.1
Coordinates 1980002..1980466 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag CGP90_RS10360 Protein ID WP_001260487.1
Coordinates 1979666..1979989 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP90_RS10300 1974698..1975123 - 426 WP_000934384.1 single-stranded DNA-binding protein -
CGP90_RS10305 1975123..1975746 - 624 WP_000139720.1 DUF1071 domain-containing protein -
CGP90_RS10310 1975739..1975960 - 222 WP_000815403.1 DUF2483 family protein -
CGP90_RS10315 1975970..1976230 - 261 WP_000291076.1 DUF1108 family protein -
CGP90_RS10320 1976324..1976485 - 162 WP_000066026.1 DUF1270 family protein -
CGP90_RS15390 1976478..1976615 - 138 WP_000230552.1 hypothetical protein -
CGP90_RS10325 1976665..1976895 + 231 WP_000395455.1 hypothetical protein -
CGP90_RS15395 1976870..1977046 - 177 WP_172844570.1 hypothetical protein -
CGP90_RS10330 1977062..1977814 - 753 WP_023487064.1 phage antirepressor KilAC domain-containing protein -
CGP90_RS10335 1977816..1978001 - 186 WP_000933363.1 helix-turn-helix domain-containing protein -
CGP90_RS10340 1978441..1978650 + 210 WP_000642492.1 hypothetical protein -
CGP90_RS10345 1978640..1978783 - 144 WP_000939498.1 hypothetical protein -
CGP90_RS10350 1978798..1979241 - 444 WP_023487065.1 hypothetical protein -
CGP90_RS10355 1979254..1979502 - 249 WP_000272859.1 helix-turn-helix domain-containing protein -
CGP90_RS10360 1979666..1979989 + 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
CGP90_RS10365 1980002..1980466 + 465 WP_000525007.1 hypothetical protein Toxin
CGP90_RS10370 1980498..1981178 + 681 WP_000392109.1 type II toxin-antitoxin system PemK/MazF family toxin -
CGP90_RS10375 1981385..1982770 + 1386 WP_000861313.1 recombinase family protein -
CGP90_RS10380 1982887..1983060 - 174 WP_000290472.1 50S ribosomal protein L32 -
CGP90_RS10390 1983140..1983697 - 558 WP_000872158.1 DUF177 domain-containing protein -
CGP90_RS10395 1983824..1984963 + 1140 WP_000843611.1 nucleotidyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1939796..1987932 48136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T79890 WP_000525007.1 NZ_CP022894:1980002-1980466 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T79890 NZ_CP022894:1980002-1980466 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT79890 WP_001260487.1 NZ_CP022894:1979666-1979989 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT79890 NZ_CP022894:1979666-1979989 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References