Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 889079..889556 Replicon chromosome
Accession NZ_CP022894
Organism Staphylococcus aureus strain 191

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CGP90_RS04495 Protein ID WP_000052076.1
Coordinates 889079..889267 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGP90_RS04500 Protein ID WP_001059690.1
Coordinates 889296..889556 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP90_RS04465 885073..885594 + 522 WP_000824485.1 hypothetical protein -
CGP90_RS04470 885935..886621 + 687 WP_000141557.1 thermonuclease family protein -
CGP90_RS04475 886978..887178 + 201 WP_001059082.1 cold-shock protein -
CGP90_RS04480 887670..887888 - 219 WP_000005886.1 hypothetical protein -
CGP90_RS04485 887950..888234 - 285 WP_001004399.1 hypothetical protein -
CGP90_RS04490 888322..888891 - 570 WP_001106654.1 hypothetical protein -
CGP90_RS04495 889079..889267 - 189 WP_000052076.1 hypothetical protein Toxin
CGP90_RS04500 889296..889556 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGP90_RS04505 889897..890100 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGP90_RS04510 890097..890333 - 237 WP_000349581.1 hypothetical protein -
CGP90_RS04515 890558..891139 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CGP90_RS04520 891212..891829 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CGP90_RS04525 891984..892478 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CGP90_RS04530 892877..893299 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CGP90_RS04535 893447..894163 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-65)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T79882 WP_000052076.1 NZ_CP022894:c889267-889079 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T79882 NZ_CP022894:c889267-889079 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT79882 WP_001059690.1 NZ_CP022894:c889556-889296 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT79882 NZ_CP022894:c889556-889296 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References