Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1979665..1980465 Replicon chromosome
Accession NZ_CP022893
Organism Staphylococcus aureus strain 61

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag CGP89_RS10365 Protein ID WP_000525007.1
Coordinates 1980001..1980465 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag CGP89_RS10360 Protein ID WP_001260487.1
Coordinates 1979665..1979988 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP89_RS10300 1974697..1975122 - 426 WP_000934384.1 single-stranded DNA-binding protein -
CGP89_RS10305 1975122..1975745 - 624 WP_000139720.1 DUF1071 domain-containing protein -
CGP89_RS10310 1975738..1975959 - 222 WP_000815403.1 DUF2483 family protein -
CGP89_RS10315 1975969..1976229 - 261 WP_000291076.1 DUF1108 family protein -
CGP89_RS10320 1976323..1976484 - 162 WP_000066026.1 DUF1270 family protein -
CGP89_RS10325 1976664..1976894 + 231 WP_000395455.1 hypothetical protein -
CGP89_RS10330 1977061..1977813 - 753 WP_023487064.1 phage antirepressor KilAC domain-containing protein -
CGP89_RS10335 1977815..1978000 - 186 WP_000933363.1 helix-turn-helix domain-containing protein -
CGP89_RS10340 1978440..1978649 + 210 WP_000642492.1 hypothetical protein -
CGP89_RS10345 1978639..1978782 - 144 WP_000939498.1 hypothetical protein -
CGP89_RS10350 1978797..1979240 - 444 WP_023487065.1 hypothetical protein -
CGP89_RS10355 1979253..1979501 - 249 WP_000272859.1 helix-turn-helix domain-containing protein -
CGP89_RS10360 1979665..1979988 + 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
CGP89_RS10365 1980001..1980465 + 465 WP_000525007.1 hypothetical protein Toxin
CGP89_RS10370 1980497..1981177 + 681 WP_000392109.1 type II toxin-antitoxin system PemK/MazF family toxin -
CGP89_RS10375 1981384..1982769 + 1386 WP_000861313.1 recombinase family protein -
CGP89_RS10380 1982886..1983059 - 174 WP_000290472.1 50S ribosomal protein L32 -
CGP89_RS10390 1983139..1983696 - 558 WP_000872158.1 DUF177 domain-containing protein -
CGP89_RS10395 1983823..1984962 + 1140 WP_000843611.1 nucleotidyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1939795..1987931 48136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T79874 WP_000525007.1 NZ_CP022893:1980001-1980465 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T79874 NZ_CP022893:1980001-1980465 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT79874 WP_001260487.1 NZ_CP022893:1979665-1979988 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT79874 NZ_CP022893:1979665-1979988 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References