Detailed information of TA system TA079867

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 931411..931940
• Replicon: chromosome
• Accession: NZ_CP022893
• Organism: Staphylococcus aureus strain 61

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: CGP89_RS04760
• Protein ID: WP_000621175.1
• Coordinates: 931578..931940 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: CGP89_RS04755
• Protein ID: WP_000948331.1
• Coordinates: 931411..931581 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP89_RS04725	926448..927008	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
CGP89_RS04730	927216..927695	+	480	WP_001287087.1	hypothetical protein	-
CGP89_RS04735	927688..929271	+	1584	WP_001294626.1	PH domain-containing protein	-
CGP89_RS04740	929258..929749	+	492	WP_001205912.1	PH domain-containing protein	-
CGP89_RS04745	929753..930112	+	360	WP_000581197.1	holo-ACP synthase	-
CGP89_RS04750	930178..931326	+	1149	WP_001281154.1	alanine racemase	-
CGP89_RS04755	931411..931581	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
CGP89_RS04760	931578..931940	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CGP89_RS04770	932290..933291	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
CGP89_RS04775	933410..933736	+	327	WP_001052491.1	anti-sigma factor antagonist	-
CGP89_RS04780	933738..934217	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
CGP89_RS04785	934192..934962	+	771	WP_001041111.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T79867 WP_000621175.1 NZ_CP022893:931578-931940 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T79867 NZ_CP022893:931578-931940 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT79867 WP_000948331.1 NZ_CP022893:931411-931581 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT79867 NZ_CP022893:931411-931581 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1