Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 889078..889555 Replicon chromosome
Accession NZ_CP022893
Organism Staphylococcus aureus strain 61

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CGP89_RS04495 Protein ID WP_000052076.1
Coordinates 889078..889266 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGP89_RS04500 Protein ID WP_001059690.1
Coordinates 889295..889555 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP89_RS04465 885072..885593 + 522 WP_000824485.1 hypothetical protein -
CGP89_RS04470 885934..886620 + 687 WP_000141557.1 thermonuclease family protein -
CGP89_RS04475 886977..887177 + 201 WP_001059082.1 cold-shock protein -
CGP89_RS04480 887669..887887 - 219 WP_000005886.1 hypothetical protein -
CGP89_RS04485 887949..888233 - 285 WP_001004399.1 hypothetical protein -
CGP89_RS04490 888321..888890 - 570 WP_001106654.1 hypothetical protein -
CGP89_RS04495 889078..889266 - 189 WP_000052076.1 hypothetical protein Toxin
CGP89_RS04500 889295..889555 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGP89_RS04505 889896..890099 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGP89_RS04510 890096..890332 - 237 WP_000349581.1 hypothetical protein -
CGP89_RS04515 890557..891138 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CGP89_RS04520 891211..891828 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CGP89_RS04525 891983..892477 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CGP89_RS04530 892876..893298 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CGP89_RS04535 893446..894162 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T79866 WP_000052076.1 NZ_CP022893:c889266-889078 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T79866 NZ_CP022893:c889266-889078 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT79866 WP_001059690.1 NZ_CP022893:c889555-889295 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT79866 NZ_CP022893:c889555-889295 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References