Detailed information of TA system TA079855

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 837921..838453
• Replicon: chromosome
• Accession: NZ_CP022892
• Organism: Staphylococcus aureus strain 54

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: CGP87_RS04265
• Protein ID: WP_001103942.1
• Coordinates: 838133..838453 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: CGP87_RS04260
• Protein ID: WP_001058486.1
• Coordinates: 837921..838130 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP87_RS04215	832940..834160	-	1221	WP_000266157.1	site-specific integrase	-
CGP87_RS04220	834249..834977	-	729	WP_000733775.1	staphylococcal enterotoxin type K	-
CGP87_RS04225	835001..835729	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
CGP87_RS04230	835799..836230	-	432	WP_001228759.1	hypothetical protein	-
CGP87_RS04235	836247..836705	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
CGP87_RS04240	836717..837049	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
CGP87_RS04245	837242..837505	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
CGP87_RS04250	837498..837770	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
CGP87_RS04255	837782..837928	+	147	WP_000784875.1	hypothetical protein	-
CGP87_RS04260	837921..838130	+	210	WP_001058486.1	hypothetical protein	Antitoxin
CGP87_RS04265	838133..838453	+	321	WP_001103942.1	DUF1474 family protein	Toxin
CGP87_RS04270	838517..839386	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
CGP87_RS04275	839403..840860	+	1458	WP_000390455.1	virulence-associated E family protein	-
CGP87_RS04280	841161..841523	+	363	WP_001039168.1	hypothetical protein	-
CGP87_RS04285	841525..841809	+	285	WP_000998181.1	hypothetical protein	-
CGP87_RS04290	841806..842447	+	642	WP_001019764.1	hypothetical protein	-
CGP87_RS04295	842964..843305	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	814991..848255	33264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T79855 WP_001103942.1 NZ_CP022892:838133-838453 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T79855 NZ_CP022892:838133-838453 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT79855 WP_001058486.1 NZ_CP022892:837921-838130 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT79855 NZ_CP022892:837921-838130 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4