Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 820308..820785 Replicon chromosome
Accession NZ_CP022892
Organism Staphylococcus aureus strain 54

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag CGP87_RS04110 Protein ID WP_000052078.1
Coordinates 820308..820496 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGP87_RS04115 Protein ID WP_001059690.1
Coordinates 820525..820785 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP87_RS04080 816349..816819 + 471 WP_000824472.1 hypothetical protein -
CGP87_RS04085 817160..817846 + 687 WP_001548082.1 thermonuclease family protein -
CGP87_RS04090 818203..818403 + 201 WP_001059082.1 cold-shock protein -
CGP87_RS04095 818899..819117 - 219 WP_000005886.1 hypothetical protein -
CGP87_RS04100 819179..819463 - 285 WP_001004395.1 hypothetical protein -
CGP87_RS04105 819551..820120 - 570 WP_001106654.1 hypothetical protein -
CGP87_RS04110 820308..820496 - 189 WP_000052078.1 hypothetical protein Toxin
CGP87_RS04115 820525..820785 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGP87_RS04120 821126..821329 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGP87_RS04125 821326..821562 - 237 WP_000368687.1 hypothetical protein -
CGP87_RS04130 821787..822368 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
CGP87_RS04135 822441..823058 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CGP87_RS04140 823213..823707 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CGP87_RS04145 824106..824528 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CGP87_RS04150 824676..825392 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 814991..848255 33264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T79854 WP_000052078.1 NZ_CP022892:c820496-820308 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T79854 NZ_CP022892:c820496-820308 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT79854 WP_001059690.1 NZ_CP022892:c820785-820525 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT79854 NZ_CP022892:c820785-820525 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References