Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 3699875..3700791 Replicon chromosome
Accession NZ_CP022891
Organism Bacillus subtilis strain DKU_NT_03

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag CJZ71_RS19685 Protein ID WP_003244695.1
Coordinates 3700045..3700791 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag CJZ71_RS19680 Protein ID WP_003232646.1
Coordinates 3699875..3700045 (-) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJZ71_RS19650 3696734..3697063 + 330 WP_014479562.1 XkdW family protein -
CJZ71_RS19655 3697060..3697224 + 165 WP_014479563.1 XkdX family protein -
CJZ71_RS19660 3697271..3698110 + 840 WP_014479564.1 phage-like element PBSX protein XepA -
CJZ71_RS19665 3698163..3698432 + 270 WP_014479565.1 hemolysin XhlA family protein -
CJZ71_RS19670 3698445..3698708 + 264 WP_014479566.1 phage holin -
CJZ71_RS19675 3698721..3699614 + 894 WP_014479567.1 N-acetylmuramoyl-L-alanine amidase -
CJZ71_RS22520 3699652..3699789 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
CJZ71_RS19680 3699875..3700045 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
CJZ71_RS19685 3700045..3700791 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
CJZ71_RS19690 3700901..3701902 - 1002 WP_014479569.1 inorganic phosphate transporter -
CJZ71_RS19695 3701915..3702532 - 618 WP_003218470.1 DUF47 domain-containing protein -
CJZ71_RS19700 3702908..3704260 - 1353 WP_014478984.1 IS1182 family transposase -
CJZ71_RS19705 3704390..3705706 - 1317 WP_014479570.1 serine/threonine exchanger -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3661485..3722792 61307
- flank IS/Tn - - 3702908..3704260 1352


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-238)

Antitoxin

(1-56)


Sequences


Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T79853 WP_003244695.1 NZ_CP022891:c3700791-3700045 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T79853 NZ_CP022891:c3700791-3700045 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAACTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCCTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCCTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT79853 WP_003232646.1 NZ_CP022891:c3700045-3699875 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT79853 NZ_CP022891:c3700045-3699875 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3O6Q


Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References