Detailed information of TA system TA079849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 2423856..2424421
• Replicon: chromosome
• Accession: NZ_CP022889
• Organism: Tsuneonella mangrovi strain C9-11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CJO11_RS11810
• Protein ID: WP_095012886.1
• Coordinates: 2424044..2424421 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CJO11_RS11805
• Protein ID: WP_095012885.1
• Coordinates: 2423856..2424047 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJO11_RS11780	2419730..2420188	+	459	WP_095012880.1	DUF4281 domain-containing protein	-
CJO11_RS11785	2420237..2420368	-	132	WP_095012881.1	entericidin A/B family lipoprotein	-
CJO11_RS11790	2420470..2420706	+	237	WP_095012882.1	hypothetical protein	-
CJO11_RS11795	2420731..2422254	-	1524	WP_205651073.1	Flp pilus assembly complex ATPase component TadA	-
CJO11_RS11800	2422472..2423767	+	1296	WP_095012884.1	O-antigen ligase family protein	-
CJO11_RS11805	2423856..2424047	+	192	WP_095012885.1	ribbon-helix-helix protein, CopG family	Antitoxin
CJO11_RS11810	2424044..2424421	+	378	WP_095012886.1	type II toxin-antitoxin system VapC family toxin	Toxin
CJO11_RS11815	2424425..2426248	+	1824	WP_095012887.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
CJO11_RS11820	2426469..2428721	+	2253	WP_095013388.1	GGDEF and EAL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-106)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-38)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14206.18 Da
• Isoelectric Point: 5.8864

>T79849 WP_095012886.1 NZ_CP022889:2424044-2424421 [Tsuneonella mangrovi]
MTEAVFDTDILTDALRNVRPAQSELMRYSQRYISRLSWIEVMIQSMPDDSARTESYLDHFRIIEVSEDVARQAATLRSQR
RSLKALDAIVLASAQTTGRVLVTRNTADFPAEMPGVRVPYTVKDL

Nucleotide

• Length: 378 bp

>T79849 NZ_CP022889:2424044-2424421 [Tsuneonella mangrovi]
ATGACCGAGGCGGTGTTCGATACCGATATCCTGACTGACGCATTGCGCAACGTGCGGCCCGCGCAATCCGAACTGATGCG
CTATTCGCAGCGCTATATCAGCCGGTTGAGCTGGATCGAGGTCATGATCCAGTCGATGCCCGACGATAGCGCTCGCACCG
AAAGCTATCTCGATCATTTCCGGATAATCGAAGTCAGCGAAGATGTTGCCAGGCAAGCTGCGACCTTGCGTTCGCAGCGC
CGCTCGCTCAAGGCGCTCGACGCTATTGTCCTGGCATCGGCCCAGACCACAGGCCGTGTGCTGGTCACCCGCAACACCGC
AGATTTCCCGGCCGAAATGCCGGGGGTCCGCGTTCCCTATACTGTGAAGGACCTGTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7023.78 Da
• Isoelectric Point: 4.6544

>AT79849 WP_095012885.1 NZ_CP022889:2423856-2424047 [Tsuneonella mangrovi]
MARILADLPDDDIRWLDQLAQEQGKSRAAVLREAVAAYRGSTGGEGIERFFGIWRDRSDGQTS

Nucleotide

• Length: 192 bp

>AT79849 NZ_CP022889:2423856-2424047 [Tsuneonella mangrovi]
ATGGCCCGAATCCTCGCAGACCTTCCCGATGACGATATCCGCTGGCTCGACCAGTTGGCGCAGGAGCAGGGAAAGTCACG
CGCAGCGGTCTTGCGTGAAGCGGTTGCTGCCTATCGCGGGAGTACGGGGGGCGAAGGGATCGAGCGTTTCTTCGGGATTT
GGCGAGATCGCAGTGACGGTCAGACGTCATGA