Detailed information of TA system TA079829

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 990973..991779
• Replicon: chromosome
• Accession: NZ_CP022881
• Organism: Staphylococcus sp. M0911

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: ssp1_RS04945
• Protein ID: WP_049425065.1
• Coordinates: 991600..991779 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: ssp1_RS04940
• Protein ID: WP_002452098.1
• Coordinates: 990973..991572 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ssp1_RS04920	986758..988218	+	1461	WP_075779011.1	ABC transporter substrate-binding protein/permease	-
ssp1_RS04925	988211..988933	+	723	WP_002452095.1	amino acid ABC transporter ATP-binding protein	-
ssp1_RS04930	989191..990321	+	1131	WP_075779012.1	tRNA epoxyqueuosine(34) reductase QueG	-
ssp1_RS04935	990322..990792	+	471	WP_002452097.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
ssp1_RS04940	990973..991572	+	600	WP_002452098.1	glucosamine-6-phosphate isomerase	Antitoxin
ssp1_RS04945	991600..991779	+	180	WP_049425065.1	hypothetical protein	Toxin
ssp1_RS04950	991933..992325	+	393	WP_002452100.1	hypothetical protein	-
ssp1_RS04955	992480..993865	+	1386	WP_107533114.1	class II fumarate hydratase	-
ssp1_RS04960	993924..994754	-	831	WP_118828141.1	RluA family pseudouridine synthase	-
ssp1_RS04965	994932..996044	+	1113	WP_002452103.1	GAF domain-containing sensor histidine kinase	-
ssp1_RS04970	996065..996688	+	624	WP_002452104.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6943.26 Da
• Isoelectric Point: 3.8537

>T79829 WP_049425065.1 NZ_CP022881:991600-991779 [Staphylococcus sp. M0911]
MTQNKDSRTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEDKLNQSHDSEVRSDLDQE

Nucleotide

• Length: 180 bp

>T79829 NZ_CP022881:991600-991779 [Staphylococcus sp. M0911]
ATGACTCAAAATAAAGATTCTAGAACGAATTACCACGAAGAAGAAAATGCAATGGTAACTGATTTAGATGATTTAAAAGA
TTTAGGTAAAGAAATGGAACAAATTTCTGAAGAAAATGATGAAGATAAATTAAATCAATCTCATGATTCAGAAGTGCGTT
CTGATTTAGATCAAGAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22575.46 Da
• Isoelectric Point: 4.8492

>AT79829 WP_002452098.1 NZ_CP022881:990973-991572 [Staphylococcus sp. M0911]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDENQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDESGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT79829 NZ_CP022881:990973-991572 [Staphylococcus sp. M0911]
ATGGCAATGAACTTTAAAGTATTTGAAGATAAGCAAAGAGTAGCTGAATATACAGCGGATATTTTGAGAAAACAATTTAA
TAACAACCCAATGACTATCGCAGGTGTTCATTTAACAAAAGATCATGCACCTGTATTAGATGAATTAAAAAAGAATGTTG
ATTTACATGCAGTTGACTTCAGTCAAATTAACATTTTAGATTATGATGAAAATCAATCATATTATGAAGCGTTAGGTGTA
CCACAAAGTCAAATTTATTCATTATCATACAATCAAGATGCTAATGACTTTATTTCAGATAAAATTAAAACCAAAGAAAA
TAAAGGTAAATTAGTATTACAAGTGGTTTCAATTGATGAAAGCGGTAATTTAGACGTAAGTGTTAGACAAGGTTTATTAG
AAGCACGTGAAATCTTCTTAGTTGTTACTGGTAGTAATAAACGTGAAGTAGTTGAAAAATTATATAATGAAAATGGAAAA
TCTAATTTTGAACCAGCAGACTTAAAAGCGCACCGTATGGTTAACGTTATTTTAGATAAAGAAGCAGCAGCTGGATTACC
TGAAGACGTAAAAGAATACTTCACAGCTCGCTTTGCATAA