Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 847683..848212 Replicon chromosome
Accession NZ_CP022881
Organism Staphylococcus sp. M0911

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag ssp1_RS04110 Protein ID WP_002451625.1
Coordinates 847850..848212 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag ssp1_RS04105 Protein ID WP_002451626.1
Coordinates 847683..847853 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ssp1_RS04080 843508..843981 + 474 WP_107536262.1 PH domain-containing protein -
ssp1_RS04085 843974..845500 + 1527 WP_075778730.1 PH domain-containing protein -
ssp1_RS04090 845487..845984 + 498 WP_075778713.1 PH domain-containing protein -
ssp1_RS04095 846017..846391 + 375 WP_075778712.1 holo-ACP synthase -
ssp1_RS04100 846443..847591 + 1149 WP_002451627.1 alanine racemase -
ssp1_RS04105 847683..847853 + 171 WP_002451626.1 hypothetical protein Antitoxin
ssp1_RS04110 847850..848212 + 363 WP_002451625.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ssp1_RS04120 848539..849540 + 1002 WP_075778711.1 PP2C family protein-serine/threonine phosphatase -
ssp1_RS04125 849635..849961 + 327 WP_118828131.1 anti-sigma factor antagonist -
ssp1_RS04130 849963..850442 + 480 WP_002466768.1 anti-sigma B factor RsbW -
ssp1_RS04135 850417..851187 + 771 WP_002451621.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T79828 WP_002451625.1 NZ_CP022881:847850-848212 [Staphylococcus sp. M0911]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp

>T79828 NZ_CP022881:847850-848212 [Staphylococcus sp. M0911]
ATGATTAGAAGAGGAGACGTTTATCTAGCGGATTTATCGCCTGTTCAAGGGTCAGAACAAGGGGGAGTGAGACCCGTAGT
CATTATTCAGAATGACACAGGTAATAAATATAGTCCCACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCTA
AGATACCTACACATGTTGAGATTGAAAAGAAAAAGTACAAACTTGATAAGGATTCAGTCATTTTACTAGAACAAATTCGT
ACTTTAGATAAAAATCGTTTGAAAGAAAAACTCACATATTTGTCTGATAACAAAATGAAAGAAGTAGATTACGCCCTAGA
CATCAGTCTAGGTTTACATAATTTCAATCATTCTAAGACATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT79828 WP_002451626.1 NZ_CP022881:847683-847853 [Staphylococcus sp. M0911]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT79828 NZ_CP022881:847683-847853 [Staphylococcus sp. M0911]
ATGTTATCTTTTAATCAAAATAGAAGTTACAGTTTAGAGCAATCTTTAAAAGAAGGTTATGCACAAATGGCTGATTTAAA
TCTCTCCCTAGCAACCGAAGCTTTTCCTATTGAATGTGAAGCGTGCGATTGCAATGAAACATATTTAACTTCTAATGCTA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PXE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References