Detailed information of TA system TA079827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 836561..837071
• Replicon: chromosome
• Accession: NZ_CP022881
• Organism: Staphylococcus sp. M0911

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: ssp1_RS04050
• Protein ID: WP_002451637.1
• Coordinates: 836865..837071 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: ssp1_RS04045
• Protein ID: WP_002451638.1
• Coordinates: 836561..836854 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ssp1_RS04020	831686..832477	+	792	WP_075778720.1	hydroxyethylthiazole kinase	-
ssp1_RS04025	832478..833119	+	642	WP_075778719.1	thiamine phosphate synthase	-
ssp1_RS04030	833207..834076	+	870	WP_002451641.1	membrane protein insertase YidC	-
ssp1_RS04035	834116..834760	-	645	WP_075778718.1	HD domain-containing protein	-
ssp1_RS04040	834888..836372	-	1485	WP_075778717.1	cardiolipin synthase	-
ssp1_RS04045	836561..836854	+	294	WP_002451638.1	copper-sensing transcriptional repressor CsoR	Antitoxin
ssp1_RS04050	836865..837071	+	207	WP_002451637.1	heavy-metal-associated domain-containing protein	Toxin
ssp1_RS04055	837211..837348	+	138	WP_002451636.1	hypothetical protein	-
ssp1_RS04060	837486..838676	-	1191	WP_049425344.1	rod shape-determining protein RodA	-
ssp1_RS04065	839035..840105	+	1071	WP_002451634.1	D-alanine--D-alanine ligase	-
ssp1_RS04070	840121..841482	+	1362	WP_118828130.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (19-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7686.62 Da
• Isoelectric Point: 3.8774

>T79827 WP_002451637.1 NZ_CP022881:836865-837071 [Staphylococcus sp. M0911]
VQQKIVYTAGIETQEQSESVKNLLTEMIGVYQVEIDINTGNISIEFETPANLNSIEKEIYDAGYKVLY

Nucleotide

• Length: 207 bp

>T79827 NZ_CP022881:836865-837071 [Staphylococcus sp. M0911]
GTGCAACAAAAAATTGTTTATACAGCTGGTATAGAAACACAAGAACAATCTGAATCTGTAAAAAATCTTTTAACTGAAAT
GATAGGTGTATATCAAGTTGAAATCGATATCAATACTGGAAACATTTCAATAGAATTTGAAACACCTGCGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGCTGGATATAAAGTCCTCTATTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11159.63 Da
• Isoelectric Point: 6.3270

>AT79827 WP_002451638.1 NZ_CP022881:836561-836854 [Staphylococcus sp. M0911]
VTEQDHAHHSEQSKANLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIAEKVNQGHQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT79827 NZ_CP022881:836561-836854 [Staphylococcus sp. M0911]
GTGACAGAACAAGATCATGCGCATCACTCTGAACAAAGTAAAGCAAATTTAAAATCGAGATTAAACCGTATTGAAGGTCA
AGTGAGAGCTATTAATCGAATGATAGAAGAAGATGTATATTGCGATGATGTGTTAACTCAAATCAGAGCTACACGTTCTG
CATTAAATAGCGTAGCTACTAAATTATTAGAACAACATATGAAAAGTTGTATTGCAGAAAAAGTTAATCAAGGACATCAA
GAAGAGGCAATGGAAGAGCTACTCGTTACTTTTCAAAAACTTATGAAAGATTGA