Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 836561..837071 Replicon chromosome
Accession NZ_CP022881
Organism Staphylococcus sp. M0911

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag ssp1_RS04050 Protein ID WP_002451637.1
Coordinates 836865..837071 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag ssp1_RS04045 Protein ID WP_002451638.1
Coordinates 836561..836854 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ssp1_RS04020 831686..832477 + 792 WP_075778720.1 hydroxyethylthiazole kinase -
ssp1_RS04025 832478..833119 + 642 WP_075778719.1 thiamine phosphate synthase -
ssp1_RS04030 833207..834076 + 870 WP_002451641.1 membrane protein insertase YidC -
ssp1_RS04035 834116..834760 - 645 WP_075778718.1 HD domain-containing protein -
ssp1_RS04040 834888..836372 - 1485 WP_075778717.1 cardiolipin synthase -
ssp1_RS04045 836561..836854 + 294 WP_002451638.1 copper-sensing transcriptional repressor CsoR Antitoxin
ssp1_RS04050 836865..837071 + 207 WP_002451637.1 heavy-metal-associated domain-containing protein Toxin
ssp1_RS04055 837211..837348 + 138 WP_002451636.1 hypothetical protein -
ssp1_RS04060 837486..838676 - 1191 WP_049425344.1 rod shape-determining protein RodA -
ssp1_RS04065 839035..840105 + 1071 WP_002451634.1 D-alanine--D-alanine ligase -
ssp1_RS04070 840121..841482 + 1362 WP_118828130.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7686.62 Da        Isoelectric Point: 3.8774

>T79827 WP_002451637.1 NZ_CP022881:836865-837071 [Staphylococcus sp. M0911]
VQQKIVYTAGIETQEQSESVKNLLTEMIGVYQVEIDINTGNISIEFETPANLNSIEKEIYDAGYKVLY

Download         Length: 207 bp

>T79827 NZ_CP022881:836865-837071 [Staphylococcus sp. M0911]
GTGCAACAAAAAATTGTTTATACAGCTGGTATAGAAACACAAGAACAATCTGAATCTGTAAAAAATCTTTTAACTGAAAT
GATAGGTGTATATCAAGTTGAAATCGATATCAATACTGGAAACATTTCAATAGAATTTGAAACACCTGCGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGCTGGATATAAAGTCCTCTATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11159.63 Da        Isoelectric Point: 6.3270

>AT79827 WP_002451638.1 NZ_CP022881:836561-836854 [Staphylococcus sp. M0911]
VTEQDHAHHSEQSKANLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIAEKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT79827 NZ_CP022881:836561-836854 [Staphylococcus sp. M0911]
GTGACAGAACAAGATCATGCGCATCACTCTGAACAAAGTAAAGCAAATTTAAAATCGAGATTAAACCGTATTGAAGGTCA
AGTGAGAGCTATTAATCGAATGATAGAAGAAGATGTATATTGCGATGATGTGTTAACTCAAATCAGAGCTACACGTTCTG
CATTAAATAGCGTAGCTACTAAATTATTAGAACAACATATGAAAAGTTGTATTGCAGAAAAAGTTAATCAAGGACATCAA
GAAGAGGCAATGGAAGAGCTACTCGTTACTTTTCAAAAACTTATGAAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References