79822

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1354639..1355558 Replicon chromosome
Accession NZ_CP022874
Organism Bacillus sp. 1s-1

Toxin (Protein)


Gene name spoIISA Uniprot ID T5HIF3
Locus tag CJO35_RS06950 Protein ID WP_003180879.1
Coordinates 1354812..1355558 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID T5HT37
Locus tag CJO35_RS06945 Protein ID WP_003180877.1
Coordinates 1354639..1354812 (-) Length 58 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJO35_RS06925 1350064..1351161 + 1098 WP_003180867.1 mannonate dehydratase -
CJO35_RS06930 1351137..1351985 + 849 WP_009328728.1 SDR family oxidoreductase -
CJO35_RS06935 1352012..1353025 + 1014 WP_003180872.1 zinc-binding alcohol dehydrogenase family protein -
CJO35_RS06940 1353078..1354349 + 1272 WP_011197811.1 MFS transporter -
CJO35_RS06945 1354639..1354812 - 174 WP_003180877.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
CJO35_RS06950 1354812..1355558 - 747 WP_003180879.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
CJO35_RS06955 1355669..1356667 - 999 WP_003180881.1 inorganic phosphate transporter -
CJO35_RS06960 1356680..1357297 - 618 WP_003180884.1 DUF47 domain-containing protein -
CJO35_RS06965 1357629..1359386 + 1758 WP_003180886.1 gamma-glutamyltransferase -
CJO35_RS06970 1359515..1360159 + 645 WP_009328721.1 YesL family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-238)

Antitoxin

(1-57)


Sequences


Toxin        


Download         Length: 249 a.a.        Molecular weight: 29391.80 Da        Isoelectric Point: 4.5367

>T79822 WP_003180879.1 NZ_CP022874:c1355558-1354812 [Bacillus sp. 1s-1]
MLLFYQFLVWLIVLALALYVAAVWRFEKQLAEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLDRKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEEGDD

Download         Length: 747 bp

>T79822 NZ_CP022874:c1355558-1354812 [Bacillus sp. 1s-1]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTTATTGTTTTGGCGCTGGCTCTGTACGTAGCTGCCGTGTGGCGTTTTGA
AAAACAGCTCGCCGAAAAAACGGTCGCCATCAGAAAAACGTGGTACCTTCTTTATGTCATCGGCGCCGTGATATATTGGA
CGCACGATCCGCAGTCAATTTTCACAAACCCGCTTCATTACCTGATCGTTGCCGTTTTTTTCACGTTGACAGACGCTTTT
ATTTTCTTAAATGCCTACTTTAAAAAGCTCGGCAGCTCTGAACTCGCGACAGATACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACGTATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAACGAACCGATCCACATCTATTATG
GAAATATAGAAGCGTATGCAGAAGGCATCGAAAAGCTCATCAAACGGTTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAAGATCATTTGCTTGAGCATATGGAAAACCGGTTCGATGTTCAAGAAAAGCTTGA
CCGCAAAGACGTTTATTATGAAGAAAACGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGATTATCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGAAGGTGACGACTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6945.04 Da        Isoelectric Point: 10.9186

>AT79822 WP_003180877.1 NZ_CP022874:c1354812-1354639 [Bacillus sp. 1s-1]
MEPAFQQDQESVKKRLAFKMFKRQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Download         Length: 174 bp

>AT79822 NZ_CP022874:c1354812-1354639 [Bacillus sp. 1s-1]
ATGGAGCCTGCTTTTCAGCAAGACCAGGAAAGCGTAAAAAAGCGCCTCGCCTTTAAAATGTTTAAAAGGCAATCCAAAAC
CAATATCGCGAAATACGAAGTCAGCCCCCATACCGAACGGATTTTCCGGCAAAACGAACGGCTGATCGGCGAGTATAAAA
GAAAAAAAGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB T5HIF3


Antitoxin

Source ID Structure
AlphaFold DB T5HT37

References