Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 56090..56826 Replicon plasmid pKPN1705-1
Accession NZ_CP022824
Organism Klebsiella quasivariicola strain KPN1705

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag B8P98_RS28155 Protein ID WP_003026803.1
Coordinates 56344..56826 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag B8P98_RS28150 Protein ID WP_003026799.1
Coordinates 56090..56356 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B8P98_RS28105 52152..52514 - 363 WP_004152100.1 arsenite efflux transporter metallochaperone ArsD -
B8P98_RS28110 52564..52914 - 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
B8P98_RS28115 53272..53541 + 270 WP_004152102.1 hypothetical protein -
B8P98_RS28120 53529..54104 + 576 WP_040207219.1 hypothetical protein -
B8P98_RS28125 54135..54629 + 495 WP_004152104.1 DNA-binding protein -
B8P98_RS28130 54673..55041 + 369 WP_004152105.1 hypothetical protein -
B8P98_RS28135 55075..55278 + 204 WP_004152106.1 hemolysin expression modulator Hha -
B8P98_RS28140 55327..55584 + 258 WP_004152107.1 hypothetical protein -
B8P98_RS28145 55660..55914 + 255 WP_004152108.1 hypothetical protein -
B8P98_RS28150 56090..56356 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
B8P98_RS28155 56344..56826 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
B8P98_RS28160 57022..57606 + 585 WP_009309985.1 helix-turn-helix domain-containing protein -
B8P98_RS28165 57698..57982 + 285 WP_095033675.1 transposase -
B8P98_RS28170 57979..58833 + 855 WP_077255859.1 IS3 family transposase -
B8P98_RS28175 58865..59650 + 786 Protein_61 transposase -
B8P98_RS28180 59721..60539 - 819 WP_074196144.1 abortive infection family protein -
B8P98_RS28185 60548..61120 - 573 WP_032676095.1 recombinase family protein -
B8P98_RS28190 61408..61818 - 411 WP_040210104.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..240771 240771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T79819 WP_003026803.1 NZ_CP022824:56344-56826 [Klebsiella quasivariicola]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T79819 NZ_CP022824:56344-56826 [Klebsiella quasivariicola]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT79819 WP_003026799.1 NZ_CP022824:56090-56356 [Klebsiella quasivariicola]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT79819 NZ_CP022824:56090-56356 [Klebsiella quasivariicola]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References