Detailed information of TA system TA079817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5123409..5125090
• Replicon: chromosome
• Accession: NZ_CP022823
• Organism: Klebsiella quasivariicola strain KPN1705

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: B8P98_RS25800
• Protein ID: WP_080924696.1
• Coordinates: 5123409..5124284 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A223UHG0
• Locus tag: B8P98_RS25805
• Protein ID: WP_040971113.1
• Coordinates: 5124332..5125090 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B8P98_RS25780	5118715..5120235	+	1521	WP_025712561.1	sugar ABC transporter ATP-binding protein	-
B8P98_RS25785	5120232..5121230	+	999	WP_002885172.1	ribose ABC transporter permease	-
B8P98_RS25790	5121261..5122202	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
B8P98_RS25795	5122277..5123284	+	1008	WP_080924695.1	carbohydrate kinase family protein	-
B8P98_RS25800	5123409..5124284	-	876	WP_080924696.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
B8P98_RS25805	5124332..5125090	-	759	WP_040971113.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
B8P98_RS25810	5125174..5125902	-	729	WP_095033555.1	response regulator transcription factor	-
B8P98_RS25815	5126175..5128322	+	2148	WP_077598918.1	formate dehydrogenase subunit alpha	-
B8P98_RS25820	5128851..5129537	+	687	WP_025712555.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 33058.14 Da
• Isoelectric Point: 5.4637

>T79817 WP_080924696.1 NZ_CP022823:c5124284-5123409 [Klebsiella quasivariicola]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMNAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKSCFTQQDVDFLLSFK
RGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T79817 NZ_CP022823:c5124284-5123409 [Klebsiella quasivariicola]
ATGCAGGTTTTACCCTATGTTGCCGTCGAACGGGAATTTGCGCTGAAAGGTGGCACGGCAATCAATCTCTTTATCCGTGA
TTTCCCACGATTATCGGTGGATATCGACCTCGCCTGGGTGCCCCTGGAAAGCAGAGCGATCGCTTTACCTCATATACGGG
ATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAGGCAGGTATGAACGCTGTATTACAAGCTAATCGTTCCGATGAG
ATGCGTGTCATTGTTACTACCGATAGCGCACAAATAAAGATAGAGGTCTCACCGGTCGCACGGGGAACATTATATCCGCC
ACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTTTTGGCTATGCCAGCCTTCCGGTGGTTTCGTTGCCCGATCTCT
ACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCATCCCAGAGATTTTTATGATGTGAAATTACTTCTTGATGCGCAG
GAGCTTAACCGTCCCATTTTCAATGGGTTTATCGCGTATTTACTTAGCCATAATCGGCCTCTGGCTGAAGTGCTTAGTCC
TCGCTGGAAAGATATTGCTGAACCCTTTTACCGTGAATTCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGA
CAGCAGTCCCCTACAGGATGATTGATGCGTTAAAATCCTGTTTCACGCAACAGGATGTCGATTTTTTGCTGTCATTTAAA
CGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAACGCGTATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATAT
TCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAGATAAACTGGAAAAGGTGTTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28683.10 Da
• Isoelectric Point: 10.1988

>AT79817 WP_040971113.1 NZ_CP022823:c5125090-5124332 [Klebsiella quasivariicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVMLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT79817 NZ_CP022823:c5125090-5124332 [Klebsiella quasivariicola]
ATGCCATCAAAATTAAACTGGCTGCTGCAAAACAGTGCTCCCGGAGATGTGATCCTTCAGTCTTGGTTAAGCCGGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACACGCAAAGTGGCTGGTTAAAAAAACGAGGCAACGGCGTATACGCGCGTGCGG
GACGTGAGCCAGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTAGCCGCTCCGGTGTATGTCGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTTCAGCTAAAACAAAACCAGTGCTGGCTGAGTATGGAAAATAAAGCGCT
GCTGCCAAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGCAAAAACTACCGGTGCTGGATGATA
AATACCGCGTAATGCTTGATGTAAAAGGGAAAAGACTCACCGGCAGTGCGCCGGAACTGGCTGCTTACGAGTTGTTGAGC
GCGGTACCGGGGACCCTCTCATTTAACCACGCGGCAGAGCTTTTCCAGGGACTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTGCTTTCTGTCAGCCAGTCCGTGCAGACCAAGCGTTTGTATCTCTTTTTCGCCAGTTTTTACGAGCATGGTTGGC
TCAGACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGTAAGCGGCAAATCGTGGTAAATGGCAAGTTCAATGCTCAA
TACCAAATCACTGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A223UHG0