Detailed information of TA system TA079816

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4947644..4948160
• Replicon: chromosome
• Accession: NZ_CP022823
• Organism: Klebsiella quasivariicola strain KPN1705

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B8P98_RS24890
• Protein ID: WP_047464552.1
• Coordinates: 4947644..4947928 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: B8P98_RS24895
• Protein ID: WP_002886901.1
• Coordinates: 4947918..4948160 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B8P98_RS24870	4943118..4943426	-	309	WP_020079792.1	PTS sugar transporter subunit IIB	-
B8P98_RS31265	4943511..4943633	+	123	WP_167382683.1	hypothetical protein	-
B8P98_RS24875	4943687..4944430	+	744	WP_095033523.1	MurR/RpiR family transcriptional regulator	-
B8P98_RS24880	4944788..4946926	+	2139	WP_095033524.1	anaerobic ribonucleoside-triphosphate reductase	-
B8P98_RS24885	4947176..4947640	+	465	WP_095033525.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
B8P98_RS24890	4947644..4947928	-	285	WP_047464552.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B8P98_RS24895	4947918..4948160	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
B8P98_RS24900	4948238..4950148	-	1911	WP_023342478.1	BglG family transcription antiterminator	-
B8P98_RS24905	4950171..4951325	-	1155	WP_095033526.1	lactonase family protein	-
B8P98_RS24910	4951482..4952222	-	741	WP_025712303.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11160.02 Da
• Isoelectric Point: 10.3787

>T79816 WP_047464552.1 NZ_CP022823:c4947928-4947644 [Klebsiella quasivariicola]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRMESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T79816 NZ_CP022823:c4947928-4947644 [Klebsiella quasivariicola]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATGGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT79816 WP_002886901.1 NZ_CP022823:c4948160-4947918 [Klebsiella quasivariicola]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT79816 NZ_CP022823:c4948160-4947918 [Klebsiella quasivariicola]
ATGGCCACGCTCAACGTTCGACTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGTCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0