79804

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 819808..820465 Replicon chromosome
Accession NZ_CP022823
Organism Klebsiella quasivariicola strain KPN1705

Toxin (Protein)


Gene name cptA Uniprot ID A0A223U6H3
Locus tag B8P98_RS04165 Protein ID WP_025712490.1
Coordinates 820055..820465 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag B8P98_RS04160 Protein ID WP_002916312.1
Coordinates 819808..820074 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B8P98_RS04140 816255..816983 - 729 WP_025712494.1 MurR/RpiR family transcriptional regulator -
B8P98_RS04145 817034..817345 + 312 WP_025712493.1 N(4)-acetylcytidine aminohydrolase -
B8P98_RS04150 817509..818168 + 660 WP_025712492.1 hemolysin III family protein -
B8P98_RS04155 818579..819562 - 984 WP_025712491.1 tRNA-modifying protein YgfZ -
B8P98_RS04160 819808..820074 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
B8P98_RS04165 820055..820465 + 411 WP_025712490.1 protein YgfX Toxin
B8P98_RS04170 820472..820993 - 522 WP_025712489.1 flavodoxin FldB -
B8P98_RS04175 821094..821990 + 897 WP_025712488.1 site-specific tyrosine recombinase XerD -
B8P98_RS04180 822013..822726 + 714 WP_080897037.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B8P98_RS04185 822732..824465 + 1734 WP_025712486.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16067.89 Da        Isoelectric Point: 11.4778

>T79804 WP_025712490.1 NZ_CP022823:820055-820465 [Klebsiella quasivariicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVMQKPAQE

Download         Length: 411 bp

>T79804 NZ_CP022823:820055-820465 [Klebsiella quasivariicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCACAGTGGTTTTCTCTGCTGCTCCACGGCGTGGTGGCGGC
CCTGGTGCTGCTGGTTCCCTGGCCGCTAAGCTACACCCCGATTTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGATTGCG
TGCGTAGCCAGCGGCGGATCCATGCTCGTCGCGGGGAGATAAAACTGCTCACCGACTCCCGTCTTCGCTGGCAAAACGCT
GAATGGGAGATCCTCGGCACACCATGGGTTATCAATAGCGGAATGTTACTGCGTTTGCGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGCGACCTGCGCCGGCTGGTGATGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT79804 WP_002916312.1 NZ_CP022823:819808-820074 [Klebsiella quasivariicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT79804 NZ_CP022823:819808-820074 [Klebsiella quasivariicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGTGGGATGCGTGAACTCGATATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGATGCTGACAAACAGCTGTTCATTCGTCTGCTGGAAAATGACGACCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A223U6H3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References