Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1422396..1424013 Replicon plasmid unnamed
Accession NZ_CP022799
Organism Ralstonia solanacearum strain SL2064

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CJO98_RS22640 Protein ID WP_075467845.1
Coordinates 1422667..1424013 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CJO98_RS22635 Protein ID WP_013210321.1
Coordinates 1422396..1422662 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJO98_RS22605 1417648..1418124 + 477 WP_075467835.1 RidA family protein -
CJO98_RS22610 1418227..1419066 + 840 WP_075467838.1 AraC family transcriptional regulator -
CJO98_RS22615 1419069..1420187 + 1119 WP_075467841.1 peptidase -
CJO98_RS22620 1420214..1420597 - 384 WP_075468668.1 VOC family protein -
CJO98_RS22625 1420837..1421280 + 444 WP_172840169.1 PGDYG domain-containing protein -
CJO98_RS22630 1421296..1422201 - 906 WP_075467842.1 hypothetical protein -
CJO98_RS22635 1422396..1422662 + 267 WP_013210321.1 helix-turn-helix domain-containing protein Antitoxin
CJO98_RS22640 1422667..1424013 + 1347 WP_075467845.1 type II toxin-antitoxin system HipA family toxin Toxin
CJO98_RS22645 1424090..1424986 + 897 WP_075467848.1 DUF2236 domain-containing protein -
CJO98_RS22650 1424990..1426558 - 1569 WP_075467852.1 MFS transporter -
CJO98_RS22655 1426651..1427601 - 951 WP_075467854.1 LysR family transcriptional regulator -
CJO98_RS22660 1427741..1428367 + 627 WP_075467857.1 FMN-dependent NADH-azoreductase -
CJO98_RS25050 1428501..1428647 - 147 WP_162897835.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgC / flgG / fliM / fliG / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..1884392 1884392


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49734.05 Da        Isoelectric Point: 7.8445

>T79801 WP_075467845.1 NZ_CP022799:1422667-1424013 [Ralstonia solanacearum]
MGRRSHTRALGLWMNGTHVGHWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPYKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPAGIGDIDAEPLTEAQIAQTLRETVAPTPLGGMPEDDGNFRIS
IAGAQEKTAFLQIDGRWYRPRGATPTSHIFKLPMGRVGNMKLDLSESVENEWLCSLVLRAYGLPIAHCRPLVFEDQKVLA
VERFDRMWRDHRGRQLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSARRDADRLMLFQSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNPHWKMQDVQRRHWLGLGQRHGIVTPEGGH
AAAIVDSLAARTPEVIRTVRALLPEDFPQPLADRILRGLQSAADRLAE

Download         Length: 1347 bp

>T79801 NZ_CP022799:1422667-1424013 [Ralstonia solanacearum]
ATGGGGCGCCGGTCGCATACGCGGGCCCTCGGGCTCTGGATGAATGGCACCCATGTCGGCCACTGGGAGCTGCACCCGCA
TCAAGGCGATGTGCTGAAGTACGCGGCGTCCTGGGTGGCCGCGCCCGAGGGGCGGCCCTTGTCGCTATCCCTGCCCTTCA
CGCCGGACAACGCGCCGTACAAAGGCCCGGCGGTCCGGGCATATTTCGAAAACCTCCTGCCGGACAGCCGCGACATCCGC
GAGCGCATTGCGCGCCGGTTCCAGGCGGGCACGACCGAGGCATTCGACCTGCTGGAGCAGATCGGCCGCGACTGCATCGG
CGCCCTGCAGGTGCTGCCCGCCGACATGGCCCCGGCCGGCATCGGCGACATCGACGCGGAGCCGCTGACCGAGGCGCAGA
TCGCGCAGACGCTGCGGGAGACGGTCGCCCCGACGCCCCTGGGCGGCATGCCGGAGGACGACGGCAATTTCCGCATCTCG
ATTGCCGGCGCGCAGGAAAAGACCGCCTTCCTCCAGATCGACGGACGCTGGTACCGCCCCCGGGGCGCGACGCCGACCAG
CCACATCTTCAAGCTGCCGATGGGGCGGGTCGGCAACATGAAGCTGGACCTGAGCGAGTCGGTGGAAAACGAATGGCTGT
GCTCCCTGGTGCTGCGGGCGTATGGGCTGCCCATCGCCCACTGCCGGCCGCTGGTGTTCGAAGACCAGAAAGTCCTGGCC
GTGGAACGGTTCGACCGCATGTGGCGGGACCACCGCGGCAGGCAGCTCATCCGCCTGCCGCAGGAAGACATGTGCCAGGC
GACGGCCACGCCCCCGCACCTGAAGTACGAGGCCGACGGCGGCCCCGGCATCGACCGCATCATGGGCCTGCTCGACGGCT
CCGCGCGCCGGGATGCCGACCGCCTGATGCTGTTCCAGAGCCAGGTGCTGTTCTGGATGCTGTGCGCGCCCGACGGCCAT
GCGAAGAACTTCAGCCTCGCGCTTCGCCCCGGCGGCGCCTACGCGCTCACGCCGCTGTACGACGTGATGTCGGCCTACCC
GCTGCTGGGCGAGGGGCCGGGCAAGCTCTCGCCGCACCGGATCCGGCTGGCAATGGCCGTCCGCTCGAAGAACCCGCACT
GGAAAATGCAAGACGTCCAGCGGCGCCACTGGCTGGGCCTGGGCCAGCGGCATGGCATCGTCACGCCCGAGGGCGGGCAT
GCGGCCGCCATCGTGGACAGTCTGGCCGCCCGGACCCCCGAGGTGATCCGCACCGTGCGCGCGCTGCTGCCGGAAGACTT
CCCGCAGCCGCTGGCCGACCGCATTCTGCGAGGGCTGCAGAGCGCCGCGGACAGGCTCGCGGAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9743.27 Da        Isoelectric Point: 11.3495

>AT79801 WP_013210321.1 NZ_CP022799:1422396-1422662 [Ralstonia solanacearum]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGMRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDASGERGR
PASDQPQW

Download         Length: 267 bp

>AT79801 NZ_CP022799:1422396-1422662 [Ralstonia solanacearum]
ATGAACGAGTTCATCGTACGCACCCCCGAGCAGTTGCCGGCGATTCTCAAGGGCTTCCGCAAACAGGCCGGGCTGAGCCA
GGCTGAACTGGCCGCCCGGATGGGCATGCGCCAGCAAACCCTCTCCGCGCTGGAGCGCAACGCAGAAAACGTGAGCGCCG
GACGGCTGATGCGCCTGTTGTCGGTGCTGGGCGTCGAGCTGGTGCTGCGCAAACCCGACGCCTCCGGCGAGCGCGGCCGC
CCGGCATCCGACCAGCCGCAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References