Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 427724..428357 Replicon chromosome
Accession NZ_CP022790
Organism Ralstonia solanacearum strain SL3103

Toxin (Protein)


Gene name vapC Uniprot ID M4UIT8
Locus tag CJO93_RS01980 Protein ID WP_016725172.1
Coordinates 427944..428357 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8XUX7
Locus tag CJO93_RS01975 Protein ID WP_011002949.1
Coordinates 427724..427957 (+) Length 78 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJO93_RS01960 423312..424607 - 1296 WP_011002952.1 MFS transporter -
CJO93_RS01965 424615..425865 - 1251 WP_096761512.1 AGE family epimerase/isomerase -
CJO93_RS01970 426060..427667 + 1608 WP_069079162.1 glucan biosynthesis protein -
CJO93_RS01975 427724..427957 + 234 WP_011002949.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CJO93_RS01980 427944..428357 + 414 WP_016725172.1 PIN domain-containing protein Toxin
CJO93_RS01985 428332..428958 - 627 WP_016725173.1 DUF1415 domain-containing protein -
CJO93_RS01990 429149..429520 + 372 WP_016725174.1 hypothetical protein -
CJO93_RS01995 429585..431081 - 1497 WP_016725175.1 glycerol kinase GlpK -
CJO93_RS02000 431243..432979 - 1737 WP_016725176.1 ABC transporter substrate-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-116)

Antitoxin

(5-37)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 15087.42 Da        Isoelectric Point: 5.5348

>T79783 WP_016725172.1 NZ_CP022790:427944-428357 [Ralstonia solanacearum]
MPATEAFFDSNVVLYLLSADTAKADAAETLLMTGGVVSVQVLNETTHVMRRKLAMPWHAIETVQEAVRAQCRVEPLTLET
HDLGRRIAERYGLSVYDALIVAAALLAGCNVLYSEDMQHGLVIEQHLRIVNPFPARA

Download         Length: 414 bp

>T79783 NZ_CP022790:427944-428357 [Ralstonia solanacearum]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8790.98 Da        Isoelectric Point: 8.7287

>AT79783 WP_011002949.1 NZ_CP022790:427724-427957 [Ralstonia solanacearum]
MQVSKWGNSLAIRLPAAVVEALQLHEGDDVEVVIAGERSFGVRRKRAARELFDRIHQYRGKLPADFIFERDQANARD

Download         Length: 234 bp

>AT79783 NZ_CP022790:427724-427957 [Ralstonia solanacearum]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB M4UIT8


Antitoxin

Source ID Structure
AlphaFold DB A0A223GR76

References