Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1485318..1486935 Replicon plasmid unnamed
Accession NZ_CP022789
Organism Ralstonia solanacearum strain SL3175

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CJO92_RS22645 Protein ID WP_118870665.1
Coordinates 1485589..1486935 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CJO92_RS22640 Protein ID WP_078222913.1
Coordinates 1485318..1485584 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJO92_RS22610 1480569..1481045 + 477 WP_013210315.1 RidA family protein -
CJO92_RS22615 1481148..1481987 + 840 WP_118870661.1 AraC family transcriptional regulator -
CJO92_RS22620 1481990..1483108 + 1119 WP_118870663.1 peptidase -
CJO92_RS22625 1483135..1483518 - 384 WP_013210318.1 VOC family protein -
CJO92_RS22630 1483758..1484201 + 444 WP_172840169.1 PGDYG domain-containing protein -
CJO92_RS22635 1484217..1485122 - 906 WP_048817081.1 hypothetical protein -
CJO92_RS22640 1485318..1485584 + 267 WP_078222913.1 helix-turn-helix domain-containing protein Antitoxin
CJO92_RS22645 1485589..1486935 + 1347 WP_118870665.1 type II toxin-antitoxin system HipA family toxin Toxin
CJO92_RS22650 1487012..1487908 + 897 WP_078222911.1 DUF2236 domain-containing protein -
CJO92_RS22655 1487912..1489480 - 1569 WP_048817082.1 MFS transporter -
CJO92_RS22660 1489573..1490523 - 951 WP_013210325.1 LysR family transcriptional regulator -
CJO92_RS22665 1490663..1491289 + 627 WP_013210326.1 FMN-dependent NADH-azoreductase -
CJO92_RS25260 1491423..1491569 - 147 WP_162899024.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / flgC / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..1986284 1986284


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49842.13 Da        Isoelectric Point: 7.8445

>T79782 WP_118870665.1 NZ_CP022789:1485589-1486935 [Ralstonia solanacearum]
MGRRSHTRALGLWMNGTHVGHWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPYKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADVAPASIGDIDAEPLTEAQIAQTLRETVAPPPLGGMPEDDGNFRIS
IAGAQEKTAFLQIDERWYRPRGATPTSHIFKLPMGRVGNMKLDLSESVENEWLCSLVLRAYGLPIAHCQPLVFEDQKVLA
VERFDRMWRDHRGRQLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSARRDADRLMLFQSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNPHWKMQDVQRRHWLGLGQRHGIVTPEGGH
AAAIVDSLVARTPEVIRTVRARLPEDFPQPLADRILRGLQSAADRLAQ

Download         Length: 1347 bp

>T79782 NZ_CP022789:1485589-1486935 [Ralstonia solanacearum]
ATGGGGCGCCGGTCGCATACGCGGGCCCTCGGGCTCTGGATGAATGGCACCCATGTCGGCCACTGGGAGCTGCACCCGCA
TCAAGGCGATGTGCTGAAGTACGCGGCGTCCTGGGTGGCCGCACCCGAGGGGCGGCCCTTGTCGCTATCCCTGCCCTTCA
CGCCGGACAACGCGCCGTACAAAGGCCCGGCGGTCCGGGCATATTTCGAAAACCTCCTGCCGGACAGCCGCGACATCCGC
GAGCGCATTGCGCGCCGGTTCCAGGCGGGCACGACCGAGGCATTCGACCTGCTGGAGCAGATCGGCCGCGACTGCATCGG
CGCCCTGCAGGTGCTGCCCGCCGACGTGGCCCCAGCCAGCATCGGCGACATCGACGCGGAGCCGCTGACCGAGGCGCAGA
TCGCGCAGACGCTGCGGGAGACGGTCGCCCCGCCGCCCCTGGGCGGCATGCCGGAGGACGACGGCAATTTCCGCATCTCG
ATTGCCGGCGCGCAGGAAAAGACCGCCTTCCTCCAGATCGACGAACGCTGGTACCGCCCCCGGGGCGCGACGCCGACCAG
CCACATCTTCAAGCTGCCGATGGGGCGGGTCGGCAACATGAAGCTGGACCTGAGCGAGTCGGTGGAAAACGAATGGCTGT
GCTCCCTGGTGCTGCGGGCGTATGGGCTGCCCATCGCCCACTGCCAGCCACTGGTGTTCGAAGACCAGAAAGTCCTGGCC
GTGGAACGGTTCGACCGCATGTGGCGGGACCACCGCGGCAGGCAGCTCATCCGCCTGCCGCAGGAAGACATGTGCCAGGC
GACGGCCACGCCCCCGCACCTGAAGTACGAGGCCGACGGCGGCCCCGGCATCGACCGCATCATGGGCCTGCTCGACGGCT
CCGCGCGCCGGGATGCCGACCGCCTGATGCTGTTCCAGAGCCAGGTGCTGTTCTGGATGCTGTGCGCGCCCGACGGCCAT
GCGAAGAACTTCAGCCTCGCGCTTCGCCCCGGCGGCGCCTACGCGCTCACGCCGCTGTACGACGTGATGTCGGCCTACCC
GCTGCTGGGCGAGGGGCCGGGCAAGCTCTCACCGCACCGGATCCGGCTGGCAATGGCCGTCCGCTCGAAGAACCCGCACT
GGAAAATGCAAGACGTCCAGCGGCGCCACTGGCTGGGCCTGGGCCAGCGGCATGGCATCGTCACGCCCGAGGGCGGGCAT
GCGGCCGCCATCGTGGACAGTCTGGTCGCCCGGACCCCCGAGGTGATCCGCACCGTGCGCGCGCGGCTGCCGGAAGACTT
CCCGCAGCCGCTGGCCGACCGCATTCTGCGGGGGCTGCAGAGCGCCGCGGACAGGCTCGCGCAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9773.30 Da        Isoelectric Point: 11.3495

>AT79782 WP_078222913.1 NZ_CP022789:1485318-1485584 [Ralstonia solanacearum]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELATRMGMRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDASGERGR
PASDQPQW

Download         Length: 267 bp

>AT79782 NZ_CP022789:1485318-1485584 [Ralstonia solanacearum]
ATGAACGAGTTCATCGTACGCACCCCCGAGCAGTTGCCGGCGATTCTCAAGGGCTTCCGCAAACAGGCCGGGCTGAGCCA
GGCTGAACTGGCCACCCGGATGGGCATGCGCCAGCAAACCCTCTCCGCACTGGAGCGCAACGCAGAAAACGTGAGCGCCG
GACGGCTGATGCGCCTGTTGTCGGTGCTGGGCGTCGAGCTGGTGCTGCGCAAACCCGACGCCTCCGGCGAGCGCGGCCGC
CCGGCATCCGACCAGCCGCAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References