Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2028655..2030250 Replicon chromosome
Accession NZ_CP022786
Organism Ralstonia solanacearum strain SL3300

Toxin (Protein)


Gene name hipA Uniprot ID A0A0S4UDK5
Locus tag CJO91_RS09755 Protein ID WP_069079583.1
Coordinates 2028655..2029992 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0S4UDK3
Locus tag CJO91_RS09760 Protein ID WP_016725279.1
Coordinates 2029996..2030250 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJO91_RS09730 2024310..2025050 + 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -
CJO91_RS09735 2025047..2025745 + 699 WP_016725453.1 protocatechuate 3,4-dioxygenase subunit alpha -
CJO91_RS09740 2025926..2026489 + 564 WP_080606483.1 RNA 2',3'-cyclic phosphodiesterase -
CJO91_RS09745 2026502..2027230 - 729 WP_011001393.1 DsbA family protein -
CJO91_RS09750 2027456..2028658 - 1203 WP_118909666.1 MFS transporter -
CJO91_RS09755 2028655..2029992 - 1338 WP_069079583.1 type II toxin-antitoxin system HipA family toxin Toxin
CJO91_RS09760 2029996..2030250 - 255 WP_016725279.1 helix-turn-helix transcriptional regulator Antitoxin
CJO91_RS09765 2030354..2031193 - 840 WP_016725278.1 oxaloacetate decarboxylase -
CJO91_RS09775 2031511..2032149 + 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
CJO91_RS09780 2032217..2032693 + 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
CJO91_RS09785 2032713..2033264 + 552 WP_016727233.1 tRNA adenosine(34) deaminase TadA -
CJO91_RS09790 2033261..2034187 + 927 WP_016727232.1 muramoyltetrapeptide carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48724.75 Da        Isoelectric Point: 6.7232

>T79777 WP_069079583.1 NZ_CP022786:c2029992-2028655 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

>T79777 NZ_CP022786:c2029992-2028655 [Ralstonia solanacearum]
ATGGCGCATCCCGAACTGCATCTGTGGATGAACGGCGAGCATGTCGGCATCTGGACCGCCAGCCGCGCCGGCGTGCCGAT
CCTGCGCTATGACGACGGTTGGCTGCGCTCGCCCAACATGCGGCCGCTGTCGCTGTCGCTGCCGATCCCGGCCGGTGTGC
CCGAGCTGCGCGGCCAGGTGGTCGACGACTACTTCGACAACCTGCTGCCCGAGGCCCAGCCCATCCGCGAGCGCGTGCGG
CGCCGCTTCGGCCTCGCCTCCACGGATGCCGCCGAATTGCTGGCCGCCATCGGCCGCGACTGCGTGGGCGCCGTGCAACT
GCTGCCGCCCGGCATGGCCCCCACCGGCTACGATCGCATCGACAGCGAGCCGCTCACCGACAGCCAGGTCGACACGCTGC
TGCGCAACCTCACCGCCACGCCCGCGCTGGGCGAGGACGCCGGCGACCCCGACGCCTTCCGCATCTCCATTGCCGGCGCG
CAGGAGAAAACCGCCCTGCTGCGCATCGGCGATGCCTGGCACCGGCCGCTGGGCGCCACGCCCACCACGCACATCCTCAA
GCTGCCGCTGGGGCTGATCGGCAACATCCGCGCCGACATGCAGGACTCGGTCGACAACGAATGGCTGTGCGCGCAGCTGC
TGGCGGCCTGGGGGCTGGAGGTGGCGCGCACCGAGATCGCCCGCTTCGGCGCCAGCAAAGTGCTGGCGGTCGAGCGCTTC
GACCGCCGCTGGATGCCGGGCAACGCCTGGATCGCGCGCCTGCCGCAGGAAGACTTCTGCCAGGCCACCGGCACGCCCGC
GCACCGCAAATACGAAAACGACGGCGGCCCCGGCATGCGCGCCTGCCTCGACCTGCTGTCCGCGTCCGAACACGCCATCG
ACGACAAGCGCCGCTTCGTGCTGGCGCAACTTGCCTTCTGGCTGCTAGCCGCCACCGACGGGCACGCGAAGAACTTCTCG
CTGGCGATCGGGCGCGGCGGGCGCTTCCGCATGACGCCGCTGTATGACGTGCTCTCGGTCTGGCCGATCATGGGCGACGG
GCCGAACCAGCTGTCGCCCTATCGCGCGCGGCTGGCGATGGCCCTGCGCGGCAAGAACGCGCATGCGCGGCTGGCCGACA
TCCACGTGCGCCACTGGCAGGCGCTGGCGGCGCAATCCGGCGTGCCGGACGCGTTCGCCGGCATGCAGGCGCTGGTCGAG
CGCGTGCCGGCGGGTCTCGAGCGGGTCGAGGCGATCCTGCCGCCCGACTTCTCGGGCCGGGTCTGGAGCAGCGTGCGCAC
CGGCGTGCTCGCGCAGGCCGAGCGCTTTCTCAACGAACTGGCGTCCGTCACCCCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8754.07 Da        Isoelectric Point: 10.4693

>AT79777 WP_016725279.1 NZ_CP022786:c2030250-2029996 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp

>AT79777 NZ_CP022786:c2030250-2029996 [Ralstonia solanacearum]
ATGGAGTCCCTGCTCTCCTCGGCGCCGCAGCTGTCGGCGCATCTGAAATCGTTGCGCAAGGCGCGCGGACTCACGCAGGC
CCAGTTGGGCGCACTGCTGGGCGTCAGCCAGAACCGCATCGCCGACATCGAAAAAGACCCGGGCGCGGTCGGCTTCGAGC
AGTTACTGCGCATCCTGCACGCGCTCGGCGCGCAGTTGACGCTGCGCACGTCCGCGCCCGCCGGCACCCCCTCCGCCGCG
CCCGCCGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4UDK5

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4UDK3

References