Detailed information of TA system TA079769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 2751103..2751764
• Replicon: chromosome
• Accession: NZ_CP022782
• Organism: Ralstonia solanacearum strain SL3755

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A9E7Z845
• Locus tag: CJO89_RS12685
• Protein ID: WP_016727753.1
• Coordinates: 2751351..2751764 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A9E7Z6P3
• Locus tag: CJO89_RS12680
• Protein ID: WP_019717749.1
• Coordinates: 2751103..2751354 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJO89_RS25860	2746598..2746747	+	150	WP_155738951.1	hypothetical protein	-
CJO89_RS25865	2746808..2747422	-	615	WP_157698853.1	hypothetical protein	-
CJO89_RS12665	2748122..2748838	+	717	WP_049800424.1	Crp/Fnr family transcriptional regulator	-
CJO89_RS26210	2749513..2749851	-	339	WP_016727784.1	glycine zipper 2TM domain-containing protein	-
CJO89_RS25870	2750125..2750340	+	216	WP_071615547.1	hypothetical protein	-
CJO89_RS12675	2750494..2750726	-	233	Protein_2462	hypothetical protein	-
CJO89_RS12680	2751103..2751354	+	252	WP_019717749.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CJO89_RS12685	2751351..2751764	+	414	WP_016727753.1	type II toxin-antitoxin system VapC family toxin	Toxin
CJO89_RS12690	2751836..2752858	-	1023	WP_086706232.1	DNA cytosine methyltransferase	-
CJO89_RS25875	2752998..2753291	+	294	WP_020371973.1	hypothetical protein	-
CJO89_RS25880	2753679..2754524	+	846	WP_157698852.1	hypothetical protein	-
CJO89_RS12705	2754758..2755402	-	645	WP_086706230.1	hypothetical protein	-
CJO89_RS25885	2755478..2755630	-	153	WP_157698851.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2747216..2771332	24116
	-	flank	IS/Tn	-	-	2745636..2746601	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15586.89 Da
• Isoelectric Point: 6.2337

>T79769 WP_016727753.1 NZ_CP022782:2751351-2751764 [Ralstonia solanacearum]
MSYLIDTNVLSELRRKAPDARVVAWMQDRPRQSLYLSVLTLGEIRKGIERLDDAARRQHLIDWLEVELPNYFLGRLLDID
AHTADRWGRLMSSAGRPLPAIDGLLAATALQHDLTLVTRNTKDFAGLDVQLINPWEA

Nucleotide

• Length: 414 bp

>T79769 NZ_CP022782:2751351-2751764 [Ralstonia solanacearum]
TTGAGTTACCTGATCGACACCAATGTCCTGTCCGAATTGCGCCGCAAAGCGCCCGATGCGCGCGTGGTGGCCTGGATGCA
GGACCGCCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAGATTCGCAAAGGTATCGAGCGGCTGGACGACG
CGGCGCGCCGCCAGCACCTGATTGACTGGCTCGAAGTGGAACTGCCGAACTACTTTCTCGGCCGATTGCTCGACATCGAT
GCGCATACCGCCGACCGCTGGGGCCGGCTGATGTCCTCGGCCGGCCGCCCCCTGCCCGCCATCGACGGCCTGCTGGCCGC
GACCGCCCTGCAACACGACCTCACGCTGGTCACGCGCAACACCAAGGATTTCGCGGGGCTCGACGTCCAGCTCATCAACC
CATGGGAAGCCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9305.49 Da
• Isoelectric Point: 5.0774

>AT79769 WP_019717749.1 NZ_CP022782:2751103-2751354 [Ralstonia solanacearum]
MQSWQMQAAKARFSDVVKRAADDGPQEITVHGRPVAVVISRALFDRLSGGGESLVSFMRQSPLADQDDVVFERERSLPRE
VEF

Nucleotide

• Length: 252 bp

>AT79769 NZ_CP022782:2751103-2751354 [Ralstonia solanacearum]
ATGCAAAGCTGGCAAATGCAGGCCGCCAAGGCGCGGTTTTCCGATGTCGTGAAGCGGGCGGCAGACGATGGCCCGCAGGA
AATCACCGTGCATGGCCGCCCGGTGGCGGTGGTGATCTCGCGCGCACTGTTCGATCGCTTGAGCGGCGGCGGTGAGTCGC
TGGTCAGCTTCATGCGCCAATCCCCGCTGGCCGACCAGGACGATGTCGTCTTTGAGCGCGAGCGCAGCCTGCCGCGCGAG
GTCGAGTTTTGA