Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1501403..1503020 Replicon plasmid unnamed
Accession NZ_CP022775
Organism Ralstonia solanacearum strain T12

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CJO85_RS22405 Protein ID WP_118884761.1
Coordinates 1501674..1503020 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CJO85_RS22400 Protein ID WP_013210321.1
Coordinates 1501403..1501669 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJO85_RS22370 (CJO85_22185) 1496654..1497130 + 477 WP_118884758.1 RidA family protein -
CJO85_RS22375 (CJO85_22190) 1497233..1498072 + 840 WP_118884759.1 AraC family transcriptional regulator -
CJO85_RS22380 (CJO85_22195) 1498075..1499193 + 1119 WP_118884760.1 peptidase -
CJO85_RS22385 (CJO85_22200) 1499220..1499603 - 384 WP_075468668.1 VOC family protein -
CJO85_RS22390 (CJO85_22205) 1499843..1500286 + 444 WP_172840169.1 PGDYG domain-containing protein -
CJO85_RS22395 (CJO85_22210) 1500302..1501207 - 906 WP_048817081.1 hypothetical protein -
CJO85_RS22400 (CJO85_22215) 1501403..1501669 + 267 WP_013210321.1 helix-turn-helix transcriptional regulator Antitoxin
CJO85_RS22405 (CJO85_22220) 1501674..1503020 + 1347 WP_118884761.1 type II toxin-antitoxin system HipA family toxin Toxin
CJO85_RS22410 (CJO85_22225) 1503097..1503993 + 897 WP_118884762.1 oxygenase MpaB family protein -
CJO85_RS22415 (CJO85_22230) 1503997..1505565 - 1569 WP_118884763.1 MDR family MFS transporter -
CJO85_RS22420 (CJO85_22235) 1505658..1506608 - 951 WP_118884764.1 LysR family transcriptional regulator -
CJO85_RS22425 (CJO85_22240) 1506748..1507374 + 627 WP_118884765.1 FMN-dependent NADH-azoreductase -
CJO85_RS24900 1507508..1507654 - 147 WP_162899671.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgC / flgG / fliM / fliG / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..1988373 1988373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49744.09 Da        Isoelectric Point: 7.8445

>T79754 WP_118884761.1 NZ_CP022775:1501674-1503020 [Ralstonia solanacearum]
MGRRSHTRALGLWMNGTHVGHWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPYKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPAGIGDIDAEPLTEAQIAQTLRETVAPPPLGGMPEDDGNFRIS
IAGAQEKTAFLQIDGRWYRPRGATPTSHIFKLPMGRVGNMKLDLSESVENEWLCSLVLRAYGLPIAHCRPLVFEDQKVLA
VERFDRMWRDHRGRQLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSARRDADRLMLFQSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNPHWKMQDVQRRHWLGLGQRHGIVTPEGGH
AAAIVDSLVARTPEVVRTVRALLPEDFPQPLADRILRGLQSAADRLAE

Download         Length: 1347 bp

>T79754 NZ_CP022775:1501674-1503020 [Ralstonia solanacearum]
ATGGGGCGCCGGTCGCATACGCGGGCCCTCGGGCTCTGGATGAATGGCACCCATGTTGGCCACTGGGAGCTGCACCCGCA
TCAAGGCGATGTGCTGAAGTACGCGGCGTCCTGGGTGGCCGCGCCCGAGGGGCGGCCCTTGTCGCTATCCCTGCCCTTCA
CGCCGGACAACGCGCCGTACAAAGGCCCGGCGGTCCGGGCATATTTCGAAAACCTCCTGCCGGACAGCCGCGACATCCGC
GAACGCATCGCGCGCCGGTTCCAGGCGGGCACGACCGAGGCATTCGACCTGCTGGAGCAGATCGGCCGCGACTGCATCGG
CGCCCTGCAGGTGCTGCCCGCCGACATGGCCCCGGCCGGCATCGGCGACATCGACGCGGAGCCGCTGACCGAGGCGCAGA
TCGCGCAGACGCTGCGGGAGACGGTCGCCCCGCCGCCCCTGGGCGGCATGCCGGAGGACGACGGCAATTTCCGCATCTCG
ATTGCCGGCGCGCAGGAAAAGACCGCCTTCCTCCAGATCGACGGACGCTGGTACCGCCCCCGGGGCGCGACGCCGACCAG
CCACATCTTCAAGCTGCCGATGGGGCGGGTCGGCAACATGAAGCTGGACCTGAGCGAGTCGGTGGAAAACGAATGGCTGT
GCTCCCTGGTGCTGCGGGCGTATGGGCTGCCCATCGCCCACTGCCGGCCGCTGGTGTTCGAAGACCAGAAAGTCCTGGCC
GTGGAACGGTTCGACCGCATGTGGCGGGACCACCGCGGCAGGCAGCTCATCCGCCTGCCGCAGGAAGACATGTGCCAGGC
GACGGCCACGCCCCCGCACCTGAAGTACGAGGCCGACGGCGGCCCTGGCATCGACCGCATCATGGGCCTGCTCGACGGCT
CCGCGCGCCGGGATGCCGACCGCCTGATGCTGTTCCAGAGCCAGGTGCTGTTCTGGATGCTGTGCGCGCCCGACGGCCAT
GCGAAGAACTTCAGCCTCGCGCTTCGCCCCGGCGGCGCCTACGCGCTCACGCCGCTGTACGACGTGATGTCGGCCTACCC
GCTGCTGGGCGAGGGGCCGGGCAAGCTCTCGCCGCACCGGATCCGGCTGGCGATGGCCGTCCGCTCCAAGAACCCGCACT
GGAAAATGCAAGACGTCCAGCGGCGCCACTGGCTGGGCCTGGGCCAGCGGCATGGCATCGTCACGCCCGAGGGCGGGCAT
GCGGCCGCCATCGTGGACAGTCTGGTCGCCCGGACCCCCGAGGTGGTCCGCACCGTGCGCGCGCTGCTGCCGGAAGACTT
CCCGCAGCCGCTGGCCGACCGCATTCTGCGAGGGCTGCAGAGCGCCGCGGACAGGCTCGCGGAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9743.27 Da        Isoelectric Point: 11.3495

>AT79754 WP_013210321.1 NZ_CP022775:1501403-1501669 [Ralstonia solanacearum]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGMRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDASGERGR
PASDQPQW

Download         Length: 267 bp

>AT79754 NZ_CP022775:1501403-1501669 [Ralstonia solanacearum]
ATGAACGAGTTCATCGTACGCACCCCCGAGCAGTTGCCAGCGATTCTCAAGGGCTTCCGCAAACAGGCCGGGCTGAGCCA
GGCTGAACTGGCCGCCCGGATGGGCATGCGCCAGCAAACCCTCTCCGCGCTGGAGCGCAACGCAGAAAACGTGAGCGCCG
GACGGCTGATGCGCCTGTTGTCGGTGCTGGGCGTCGAGCTGGTGCTGCGCAAACCCGACGCCTCCGGCGAGCGCGGCCGC
CCGGCATCCGACCAGCCGCAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References