Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1422413..1424030 Replicon plasmid unnamed
Accession NZ_CP022762
Organism Ralstonia solanacearum strain T95

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CJO78_RS22615 Protein ID WP_075467845.1
Coordinates 1422684..1424030 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CJO78_RS22610 Protein ID WP_013210321.1
Coordinates 1422413..1422679 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJO78_RS22580 1417665..1418141 + 477 WP_075467835.1 RidA family protein -
CJO78_RS22585 1418244..1419083 + 840 WP_075467838.1 AraC family transcriptional regulator -
CJO78_RS22590 1419086..1420204 + 1119 WP_075467841.1 peptidase -
CJO78_RS22595 1420231..1420614 - 384 WP_075468668.1 VOC family protein -
CJO78_RS22600 1420854..1421297 + 444 WP_172840169.1 PGDYG domain-containing protein -
CJO78_RS22605 1421313..1422218 - 906 WP_075467842.1 hypothetical protein -
CJO78_RS22610 1422413..1422679 + 267 WP_013210321.1 helix-turn-helix domain-containing protein Antitoxin
CJO78_RS22615 1422684..1424030 + 1347 WP_075467845.1 type II toxin-antitoxin system HipA family toxin Toxin
CJO78_RS22620 1424107..1425003 + 897 WP_075467848.1 DUF2236 domain-containing protein -
CJO78_RS22625 1425007..1426575 - 1569 WP_075467852.1 MFS transporter -
CJO78_RS22630 1426668..1427618 - 951 WP_075467854.1 LysR family transcriptional regulator -
CJO78_RS22635 1427758..1428384 + 627 WP_075467857.1 FMN-dependent NADH-azoreductase -
CJO78_RS25045 1428518..1428664 - 147 WP_162897835.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgC / flgG / fliM / fliG / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..1884412 1884412


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49734.05 Da        Isoelectric Point: 7.8445

>T79730 WP_075467845.1 NZ_CP022762:1422684-1424030 [Ralstonia solanacearum]
MGRRSHTRALGLWMNGTHVGHWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPYKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPAGIGDIDAEPLTEAQIAQTLRETVAPTPLGGMPEDDGNFRIS
IAGAQEKTAFLQIDGRWYRPRGATPTSHIFKLPMGRVGNMKLDLSESVENEWLCSLVLRAYGLPIAHCRPLVFEDQKVLA
VERFDRMWRDHRGRQLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSARRDADRLMLFQSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNPHWKMQDVQRRHWLGLGQRHGIVTPEGGH
AAAIVDSLAARTPEVIRTVRALLPEDFPQPLADRILRGLQSAADRLAE

Download         Length: 1347 bp

>T79730 NZ_CP022762:1422684-1424030 [Ralstonia solanacearum]
ATGGGGCGCCGGTCGCATACGCGGGCCCTCGGGCTCTGGATGAATGGCACCCATGTCGGCCACTGGGAGCTGCACCCGCA
TCAAGGCGATGTGCTGAAGTACGCGGCGTCCTGGGTGGCCGCGCCCGAGGGGCGGCCCTTGTCGCTATCCCTGCCCTTCA
CGCCGGACAACGCGCCGTACAAAGGCCCGGCGGTCCGGGCATATTTCGAAAACCTCCTGCCGGACAGCCGCGACATCCGC
GAGCGCATTGCGCGCCGGTTCCAGGCGGGCACGACCGAGGCATTCGACCTGCTGGAGCAGATCGGCCGCGACTGCATCGG
CGCCCTGCAGGTGCTGCCCGCCGACATGGCCCCGGCCGGCATCGGCGACATCGACGCGGAGCCGCTGACCGAGGCGCAGA
TCGCGCAGACGCTGCGGGAGACGGTCGCCCCGACGCCCCTGGGCGGCATGCCGGAGGACGACGGCAATTTCCGCATCTCG
ATTGCCGGCGCGCAGGAAAAGACCGCCTTCCTCCAGATCGACGGACGCTGGTACCGCCCCCGGGGCGCGACGCCGACCAG
CCACATCTTCAAGCTGCCGATGGGGCGGGTCGGCAACATGAAGCTGGACCTGAGCGAGTCGGTGGAAAACGAATGGCTGT
GCTCCCTGGTGCTGCGGGCGTATGGGCTGCCCATCGCCCACTGCCGGCCGCTGGTGTTCGAAGACCAGAAAGTCCTGGCC
GTGGAACGGTTCGACCGCATGTGGCGGGACCACCGCGGCAGGCAGCTCATCCGCCTGCCGCAGGAAGACATGTGCCAGGC
GACGGCCACGCCCCCGCACCTGAAGTACGAGGCCGACGGCGGCCCCGGCATCGACCGCATCATGGGCCTGCTCGACGGCT
CCGCGCGCCGGGATGCCGACCGCCTGATGCTGTTCCAGAGCCAGGTGCTGTTCTGGATGCTGTGCGCGCCCGACGGCCAT
GCGAAGAACTTCAGCCTCGCGCTTCGCCCCGGCGGCGCCTACGCGCTCACGCCGCTGTACGACGTGATGTCGGCCTACCC
GCTGCTGGGCGAGGGGCCGGGCAAGCTCTCGCCGCACCGGATCCGGCTGGCAATGGCCGTCCGCTCGAAGAACCCGCACT
GGAAAATGCAAGACGTCCAGCGGCGCCACTGGCTGGGCCTGGGCCAGCGGCATGGCATCGTCACGCCCGAGGGCGGGCAT
GCGGCCGCCATCGTGGACAGTCTGGCCGCCCGGACCCCCGAGGTGATCCGCACCGTGCGCGCGCTGCTGCCGGAAGACTT
CCCGCAGCCGCTGGCCGACCGCATTCTGCGAGGGCTGCAGAGCGCCGCGGACAGGCTCGCGGAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9743.27 Da        Isoelectric Point: 11.3495

>AT79730 WP_013210321.1 NZ_CP022762:1422413-1422679 [Ralstonia solanacearum]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGMRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDASGERGR
PASDQPQW

Download         Length: 267 bp

>AT79730 NZ_CP022762:1422413-1422679 [Ralstonia solanacearum]
ATGAACGAGTTCATCGTACGCACCCCCGAGCAGTTGCCGGCGATTCTCAAGGGCTTCCGCAAACAGGCCGGGCTGAGCCA
GGCTGAACTGGCCGCCCGGATGGGCATGCGCCAGCAAACCCTCTCCGCGCTGGAGCGCAACGCAGAAAACGTGAGCGCCG
GACGGCTGATGCGCCTGTTGTCGGTGCTGGGCGTCGAGCTGGTGCTGCGCAAACCCGACGCCTCCGGCGAGCGCGGCCGC
CCGGCATCCGACCAGCCGCAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References