Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 5172436..5173055 Replicon chromosome
Accession NZ_CP022752
Organism Actinopolyspora erythraea strain YIM 90600

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDG81_RS22830 Protein ID WP_198319402.1
Coordinates 5172436..5172852 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CDG81_RS22835 Protein ID WP_198319403.1
Coordinates 5172849..5173055 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDG81_RS22815 5167538..5169922 - 2385 WP_043569701.1 VanW family protein -
CDG81_RS22820 5170085..5170405 - 321 WP_043569699.1 co-chaperone GroES -
CDG81_RS22825 5170491..5172371 - 1881 WP_043569698.1 NHL domain-containing thioredoxin family protein -
CDG81_RS22830 5172436..5172852 - 417 WP_198319402.1 type II toxin-antitoxin system VapC family toxin Toxin
CDG81_RS22835 5172849..5173055 - 207 WP_198319403.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
CDG81_RS22845 5173535..5173711 - 177 WP_192827109.1 hypothetical protein -
CDG81_RS22850 5173848..5174810 - 963 WP_043569692.1 NAD(P)-dependent oxidoreductase -
CDG81_RS22855 5175143..5175781 + 639 WP_198319404.1 TetR/AcrR family transcriptional regulator -
CDG81_RS22860 5175872..5176480 - 609 WP_043569691.1 TetR/AcrR family transcriptional regulator -
CDG81_RS22865 5176864..5177538 + 675 WP_198319405.1 response regulator transcription factor -
CDG81_RS22870 5177805..5178020 - 216 WP_043569686.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(9-128)

Antitoxin

Post-segregation antitoxin CcdA

(1-42)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14931.20 Da        Isoelectric Point: 5.8947

>T79714 WP_198319402.1 NZ_CP022752:c5172852-5172436 [Actinopolyspora erythraea]
VSSAMNAVVLDASVAVDLLAGTDYAPAAIDRLARTELHAPAHLDAEVLSALGRMQRAGDLAVDDVELALDRLTAMPVTRH
PLPSLLTGTWARRADVRLLDAFYIALAEHLGLRVLTTDHRLARVCPKLTETLHLPNEQ

Download         Length: 417 bp

>T79714 NZ_CP022752:c5172852-5172436 [Actinopolyspora erythraea]
GTGAGCTCAGCGATGAACGCCGTGGTCCTGGATGCCTCCGTGGCGGTCGATCTACTCGCGGGCACCGACTACGCCCCAGC
GGCGATCGACCGTCTGGCCAGGACCGAGCTGCACGCTCCGGCGCACCTGGACGCGGAAGTTCTCTCCGCGCTCGGTCGAA
TGCAGCGCGCCGGTGACCTCGCTGTCGACGATGTCGAATTGGCCCTGGACCGCCTCACAGCCATGCCCGTTACTCGTCAC
CCGCTACCAAGTCTGCTGACGGGGACGTGGGCACGGCGCGCGGACGTGCGGCTGCTCGACGCGTTCTACATTGCGCTGGC
CGAGCACCTCGGTCTTCGGGTACTGACCACAGACCACAGACTGGCCAGGGTGTGCCCCAAGCTGACCGAGACCCTGCATC
TACCGAACGAACAGTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7351.28 Da        Isoelectric Point: 4.4610

>AT79714 WP_198319403.1 NZ_CP022752:c5173055-5172849 [Actinopolyspora erythraea]
MNVWVPDELAKRAREAHLNLSALTQAAIAAELARTDTDVWLATLPAPRGITHEAVVTALDDAREEFGA

Download         Length: 207 bp

>AT79714 NZ_CP022752:c5173055-5172849 [Actinopolyspora erythraea]
ATGAACGTGTGGGTTCCTGATGAGCTCGCAAAGCGAGCACGCGAAGCACATCTCAACCTCTCGGCGTTGACGCAGGCTGC
CATCGCCGCTGAGTTGGCGCGCACCGATACCGATGTATGGCTGGCGACGCTGCCCGCGCCGCGTGGGATCACCCATGAGG
CGGTCGTTACCGCGCTCGATGACGCGCGTGAGGAGTTCGGTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References