Detailed information of TA system TA079705

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 701552..702090
• Replicon: chromosome
• Accession: NZ_CP022742
• Organism: Vibrio qinghaiensis strain Q67

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A7X8U0Q7
• Locus tag: CCZ37_RS16785
• Protein ID: WP_019282621.1
• Coordinates: 701791..702090 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7X8YM83
• Locus tag: CCZ37_RS16780
• Protein ID: WP_017045414.1
• Coordinates: 701552..701794 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCZ37_RS16745	696919..697659	-	741	WP_094501624.1	J domain-containing protein	-
CCZ37_RS16755	697865..698371	-	507	WP_094501626.1	hypothetical protein	-
CCZ37_RS16765	698931..699041	-	111	WP_080115538.1	DUF3265 domain-containing protein	-
CCZ37_RS16770	699038..699784	-	747	WP_157729227.1	serine protease	-
CCZ37_RS16780	701552..701794	+	243	WP_017045414.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CCZ37_RS16785	701791..702090	+	300	WP_019282621.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CCZ37_RS16795	702212..702970	-	759	WP_094501516.1	hypothetical protein	-
CCZ37_RS16800	702998..703114	-	117	WP_157729228.1	DUF3265 domain-containing protein	-
CCZ37_RS16805	703174..703416	+	243	WP_072609711.1	type II toxin-antitoxin system ParD family antitoxin	-
CCZ37_RS16810	703413..703712	+	300	WP_094501630.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CCZ37_RS16815	703839..704234	-	396	WP_094182980.1	DUF3465 domain-containing protein	-
CCZ37_RS16820	704385..705353	-	969	WP_094501631.1	DUF4917 family protein	-
CCZ37_RS16825	705382..705501	-	120	WP_020977912.1	DUF3265 domain-containing protein	-
CCZ37_RS16830	705526..705816	-	291	WP_080536237.1	YkgJ family cysteine cluster protein	-
CCZ37_RS16835	705858..706034	-	177	Protein_616	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	665923..741281	75358
	-	inside	Integron	-	-	569077..720478	151401

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11662.38 Da
• Isoelectric Point: 9.8917

>T79705 WP_019282621.1 NZ_CP022742:701791-702090 [Vibrio qinghaiensis]
MKPFQLTNKAKSDLKDIALFTSRRWGREQRNIYLKQFDESFWLLAENPDIGKTCDEIRDGYRKFPQGSHVIFYQQIGSQN
IQIIRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T79705 NZ_CP022742:701791-702090 [Vibrio qinghaiensis]
ATGAAACCATTCCAACTAACCAACAAGGCAAAATCCGATTTAAAAGATATTGCCTTATTTACCTCTCGCAGGTGGGGCCG
CGAGCAACGAAATATTTATCTCAAACAATTCGATGAATCATTTTGGCTACTCGCTGAAAATCCTGATATCGGTAAAACTT
GTGATGAAATCAGAGATGGCTACCGAAAATTTCCACAAGGAAGCCATGTTATTTTTTATCAACAAATTGGTAGCCAAAAC
ATCCAGATCATAAGAATCTTGCATAAGAGTATGGATGTAAATCCAATCTTTGGCGCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8947.89 Da
• Isoelectric Point: 4.2213

>AT79705 WP_017045414.1 NZ_CP022742:701552-701794 [Vibrio qinghaiensis]
MAKNTSITLGDHFDGFISSQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGMADYDLDSFISELDSEERK

Nucleotide

• Length: 243 bp

>AT79705 NZ_CP022742:701552-701794 [Vibrio qinghaiensis]
ATGGCTAAAAATACTAGCATCACTCTCGGCGACCACTTTGATGGTTTTATTAGTAGCCAAATCCAAAGTGGACGCTATGG
CTCAGCAAGTGAAGTAATTCGTTCCGCTCTACGTTTACTCGAAACACAAGAAACGAAAATGAACACTTTACGACAACTGC
TCGTTGAAGGTGAAGAAAGTGGTATGGCTGATTATGACCTCGATTCGTTTATCAGTGAACTAGATAGCGAAGAAAGAAAA
TGA

Structures

Toxin

• AlphaFold DB: A0A7X8U0Q7

Antitoxin

• AlphaFold DB: A0A7X8YM83