Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 635365..635912 Replicon chromosome
Accession NZ_CP022742
Organism Vibrio qinghaiensis strain Q67

Toxin (Protein)


Gene name relE Uniprot ID A0A223N2K4
Locus tag CCZ37_RS16360 Protein ID WP_000229324.1
Coordinates 635365..635667 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag CCZ37_RS16365 Protein ID WP_000861987.1
Coordinates 635655..635912 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ37_RS16330 631066..631182 - 117 WP_094502140.1 DUF3265 domain-containing protein -
CCZ37_RS16335 631173..631856 - 684 WP_094501561.1 hypothetical protein -
CCZ37_RS16340 631951..632523 - 573 WP_094501563.1 hypothetical protein -
CCZ37_RS16345 634650..634769 - 120 WP_208613968.1 DUF3265 domain-containing protein -
CCZ37_RS16350 634763..635209 - 447 WP_000805118.1 hypothetical protein -
CCZ37_RS18935 635239..635355 - 117 Protein_554 DUF3265 domain-containing protein -
CCZ37_RS16360 635365..635667 - 303 WP_000229324.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCZ37_RS16365 635655..635912 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CCZ37_RS16375 636664..637632 + 969 WP_094501484.1 IS30 family transposase -
CCZ37_RS16385 639243..640715 - 1473 WP_094501567.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 631173..652812 21639
- flank IS/Tn - - 636664..637632 968
- inside Integron - - 569077..720478 151401


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11795.70 Da        Isoelectric Point: 4.9166

>T79703 WP_000229324.1 NZ_CP022742:c635667-635365 [Vibrio qinghaiensis]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDEKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T79703 NZ_CP022742:c635667-635365 [Vibrio qinghaiensis]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGATCTGAATGATATTGCTGAATACATCGCACTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTGTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCAC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGAAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGCTTAATGCTAACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT79703 WP_000861987.1 NZ_CP022742:c635912-635655 [Vibrio qinghaiensis]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT79703 NZ_CP022742:c635912-635655 [Vibrio qinghaiensis]
ATGAAAGTAGAACTCGTGACGTCACTAAAACGGCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAACCAGT
ATTGATAACTGAGCACGGAAAGCCGTCAGCTTACCTTATTGATGTAGATGATTATGAATTTATGCAAAATCGTCTAGCGA
TCCTCGAAGGCATTGCTCGTGGCGAACGAGCTCTAGCGGATGGCAAAGTGGTCAGCCATCAAGATGCTAAGGATAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A223N2K4

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References