Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 735010..736835 Replicon chromosome
Accession NZ_CP022741
Organism Vibrio qinghaiensis strain Q67

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CCZ37_RS03530 Protein ID WP_167372377.1
Coordinates 735474..736835 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CCZ37_RS03525 Protein ID WP_167372376.1
Coordinates 735010..735477 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ37_RS03500 730937..731524 - 588 WP_088731932.1 class I SAM-dependent methyltransferase -
CCZ37_RS03505 731775..732170 + 396 WP_094499758.1 ACT domain-containing protein -
CCZ37_RS03510 732414..732959 + 546 WP_094499759.1 hypothetical protein -
CCZ37_RS03515 733006..733350 - 345 WP_010320369.1 helix-turn-helix transcriptional regulator -
CCZ37_RS03520 733510..734679 - 1170 WP_094499760.1 D-alanyl-D-alanine carboxypeptidase -
CCZ37_RS03525 735010..735477 - 468 WP_167372376.1 helix-turn-helix domain-containing protein Antitoxin
CCZ37_RS03530 735474..736835 - 1362 WP_167372377.1 type II toxin-antitoxin system HipA family toxin Toxin
CCZ37_RS03545 737647..738132 - 486 WP_010319509.1 SsrA-binding protein SmpB -
CCZ37_RS03550 738249..738680 + 432 WP_010319508.1 ubiquinone-binding protein -
CCZ37_RS03555 738680..738982 + 303 WP_094499763.1 RnfH family protein -
CCZ37_RS03560 739094..739453 - 360 WP_026027472.1 outer membrane protein assembly factor BamE -
CCZ37_RS03565 739598..741262 - 1665 WP_094499764.1 DNA repair protein RecN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51349.15 Da        Isoelectric Point: 4.9821

>T79700 WP_167372377.1 NZ_CP022741:c736835-735474 [Vibrio qinghaiensis]
VEELTVQAFIRGEWINIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPISFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQINEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDMV
PKEVLIRELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYISEKLTKWGLL

Download         Length: 1362 bp

>T79700 NZ_CP022741:c736835-735474 [Vibrio qinghaiensis]
GTGGAAGAACTAACCGTACAAGCTTTTATCAGAGGTGAATGGATAAATATTGGTATTATCTCGTTCCCTAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTCAACCACCCTATCTCGTTCTTTTTTGATGATATGGGTAAACCTGGATGGCTAAAGTTTCTAGACGATATTATG
CCTAGTGGCGCTAGTAGACGATACTGGGTCAAACACCTAGATATTGAAGATCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAATTTGGCACGATGTCGCCTATTGGTAACTTAAGAATAAAAGACTCCCTTCCTGAACGCTACGAAGTCGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCTGGTGATTTCCTCGACTACGCACAGCAAAGAGGGGCAGCCGCA
GGTGGTGCAACTGGAGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGTGGTTTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGATCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTGTGGCTTCCTCGATTTGACGTTCAAATTAATGAGCA
ACAAATAGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACACTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACACCAAGGGTATAGGTTCGATACCCAAGCTTTC
GTTATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAATACTTCATTCTT
AAAGGGTGATGGAGTCATAAAGCTTGCTCCCATTTACGATTTCGCACCAATGAAAGCTGATCCTGAAGGAATTCCAAGAA
CAACAAAATGGAAAGCCCCACTAGAGGTTGGCGGAACTTACGACTTTGTCGGCATTGCAGACACCTTATCTGATATGGTG
CCAAAGGAAGTGTTAATAAGAGAGCTAGCAATTACTGCAAGTAAATGCGTAGGCCTAAAGCAGAGACTCGCTTTACGAGG
AGTACCAGAACAAATCTTGGAGATGCCAGCCGTTGGACTTAATTATATATCAGAAAAGCTGACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17138.65 Da        Isoelectric Point: 10.8420

>AT79700 WP_167372376.1 NZ_CP022741:c735477-735010 [Vibrio qinghaiensis]
MKPSSKESVQDTVTRLRAKRNQQQSKVGKNATHSIKEQTQLNTPTRSKASKNAKAVSATERKTEANKVIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLIDSEDG

Download         Length: 468 bp

>AT79700 NZ_CP022741:c735477-735010 [Vibrio qinghaiensis]
ATGAAGCCAAGCAGTAAAGAATCAGTACAAGATACGGTAACTCGTCTAAGAGCAAAGCGAAATCAACAGCAGTCCAAGGT
TGGGAAGAATGCAACTCATTCGATCAAAGAGCAAACACAACTTAATACCCCAACGAGATCGAAAGCCTCAAAAAACGCCA
AAGCAGTAAGTGCAACAGAGCGCAAAACCGAGGCAAACAAAGTCATCAAACACTTATTGCTTGGAGAGCTAACACAGGGC
CAAGCGCTGAAAAGTCTACGCATTAATATACTGGGACTCAAACAGGATGTATTCGCAAGACTTGTCGATGTCTCAAGAAA
AACACTCTCAGACATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCAAACCATTTAGCTTAA
AAATAGGGCTACTTCCTTCTTCTCCCGATGCGTTAAAATCGCTATTAATAGATAGTGAGGATGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References