Detailed information of TA system TA079698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3486086..3486660
• Replicon: chromosome
• Accession: NZ_CP022736
• Organism: Herbaspirillum sp. meg3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: hmeg3_RS15685
• Protein ID: WP_094564548.1
• Coordinates: 3486086..3486268 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: hmeg3_RS15690
• Protein ID: WP_094566394.1
• Coordinates: 3486277..3486660 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
hmeg3_RS15685	3486086..3486268	+	183	WP_094564548.1	type II toxin-antitoxin system HicA family toxin	Toxin
hmeg3_RS15690	3486277..3486660	+	384	WP_094566394.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
hmeg3_RS15695	3486896..3487246	-	351	WP_094564549.1	hypothetical protein	-
hmeg3_RS15700	3487448..3488461	-	1014	WP_094564550.1	hypothetical protein	-
hmeg3_RS15705	3488707..3489375	-	669	WP_094564551.1	response regulator transcription factor	-
hmeg3_RS15715	3489619..3490044	-	426	WP_094564553.1	hypothetical protein	-
hmeg3_RS15720	3490041..3490772	-	732	WP_094564554.1	hypothetical protein	-
hmeg3_RS15725	3490744..3491346	-	603	WP_157739285.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-121)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6510.62 Da
• Isoelectric Point: 10.9913

>T79698 WP_094564548.1 NZ_CP022736:3486086-3486268 [Herbaspirillum sp. meg3]
MGSAEIIKQLKAAGWEHVSTRGSHHKYKNPATGKSVIVPHPKKNLPQGTAKAILKQAELK

Nucleotide

• Length: 183 bp

>T79698 NZ_CP022736:3486086-3486268 [Herbaspirillum sp. meg3]
ATGGGCAGCGCTGAAATCATCAAACAACTTAAGGCGGCGGGCTGGGAACATGTTTCGACGCGGGGTAGTCACCACAAGTA
CAAGAACCCCGCGACAGGTAAGTCTGTCATCGTTCCCCATCCTAAAAAAAACCTGCCACAAGGCACGGCGAAAGCCATCT
TGAAACAAGCTGAATTGAAATGA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14331.08 Da
• Isoelectric Point: 4.2773

>AT79698 WP_094566394.1 NZ_CP022736:3486277-3486660 [Herbaspirillum sp. meg3]
MLYPLYVWKDENSAYAGRFPDLPSVFTAADELNELPAMAQEAVEAMYEGEEHIPDASSVERWRESDEYADGFWMLIAIDR
AKINTKPVRVNISLPESLLHDIDAFAESHHLTRSGFLAQAALKAMSQ

Nucleotide

• Length: 384 bp

>AT79698 NZ_CP022736:3486277-3486660 [Herbaspirillum sp. meg3]
ATGTTATATCCGCTCTATGTATGGAAAGACGAGAACAGCGCCTACGCTGGGCGCTTTCCCGATCTGCCAAGTGTTTTCAC
TGCCGCTGACGAGCTCAACGAATTGCCAGCGATGGCACAAGAGGCCGTAGAAGCGATGTATGAAGGGGAAGAACATATTC
CCGATGCGTCGTCGGTAGAGCGATGGAGAGAGTCTGACGAATATGCAGACGGCTTTTGGATGCTGATTGCTATTGATCGC
GCCAAGATCAACACTAAGCCGGTGAGAGTGAATATCTCCCTGCCAGAAAGTCTGCTGCATGACATTGACGCTTTCGCAGA
ATCTCATCATCTGACACGCTCAGGATTTCTGGCGCAGGCTGCGCTGAAAGCAATGAGCCAGTAA