Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 20108..21851 Replicon chromosome
Accession NZ_CP022736
Organism Herbaspirillum sp. meg3

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag hmeg3_RS00115 Protein ID WP_094561916.1
Coordinates 20108..21007 (+) Length 300 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag hmeg3_RS00120 Protein ID WP_094561917.1
Coordinates 21018..21851 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
hmeg3_RS00090 15967..16752 + 786 WP_050480030.1 ABC transporter ATP-binding protein -
hmeg3_RS00095 16823..17833 + 1011 WP_094561913.1 ABC transporter substrate-binding protein -
hmeg3_RS00100 17834..18694 + 861 WP_094561914.1 ABC transporter permease -
hmeg3_RS00105 18709..19485 + 777 WP_094566057.1 SDR family oxidoreductase -
hmeg3_RS00110 19538..20077 + 540 WP_094561915.1 cupin domain-containing protein -
hmeg3_RS00115 20108..21007 + 900 WP_094561916.1 alpha/beta hydrolase Toxin
hmeg3_RS00120 21018..21851 + 834 WP_094561917.1 IclR family transcriptional regulator Antitoxin
hmeg3_RS00125 21857..22672 + 816 WP_094561918.1 SDR family oxidoreductase -
hmeg3_RS00130 22665..24410 + 1746 WP_094561919.1 thiamine pyrophosphate-binding protein -
hmeg3_RS00135 24430..25230 + 801 WP_094561920.1 aspartate dehydrogenase -
hmeg3_RS00140 25250..26734 + 1485 WP_094561921.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(48-279)

Antitoxin

Transcription regulator IclR, N-terminal

(20-69)


Sequences

Toxin        


Download         Length: 300 a.a.        Molecular weight: 32335.80 Da        Isoelectric Point: 7.1997

>T79697 WP_094561916.1 NZ_CP022736:20108-21007 [Herbaspirillum sp. meg3]
MTPHAPASVTCAETLRDSLSLLEGRFSESTVDIGNGKIVSYRSCGRGPVIVLLHGISSGAASWLQCALRLEQDAQVIAWN
APGYGRSTSLPQMQPTAADYAERLEQFLEALGITNCVLVGHSLGAMMASAYVGKGYKRASRLLLISPAQGYGSEAKRERG
LKIAQERLDVLRTIGVEGMAERSPARMLSAQAGDAERAWVRWNIQWLNPAGYTQAVHMLCGDHLRAYAPRDSLGDVPATV
YCGAEDVVTTPDHSRELAWNLNLPFHLIDNAGHACYIEQPGAVAAAIRHQLSGHLYKLS

Download         Length: 900 bp

>T79697 NZ_CP022736:20108-21007 [Herbaspirillum sp. meg3]
ATGACTCCGCACGCACCCGCCTCCGTCACTTGCGCCGAAACGCTCAGGGACTCGCTGAGCCTGCTCGAAGGGCGCTTTTC
CGAAAGTACCGTCGATATCGGCAACGGCAAGATTGTGTCCTACCGCTCCTGCGGACGCGGCCCGGTCATCGTGCTGTTGC
ACGGCATCAGTTCGGGCGCGGCGTCGTGGTTGCAATGCGCGTTGCGTCTGGAGCAGGACGCTCAGGTGATCGCCTGGAAT
GCGCCTGGCTACGGTCGCTCGACGTCGCTGCCGCAAATGCAGCCGACGGCCGCCGATTATGCCGAGCGTCTGGAGCAGTT
CCTGGAAGCGCTGGGCATCACCAACTGCGTGCTGGTTGGTCATTCGCTCGGCGCCATGATGGCATCGGCCTATGTCGGCA
AGGGTTACAAGCGTGCGTCGCGCCTGCTGCTGATCAGTCCGGCGCAAGGCTACGGCAGCGAGGCCAAGCGCGAACGCGGC
CTGAAGATTGCGCAAGAACGTCTCGATGTCCTGCGTACCATCGGCGTCGAAGGCATGGCTGAGCGCAGCCCGGCGCGCAT
GCTGTCGGCGCAGGCAGGCGATGCGGAACGCGCCTGGGTGCGCTGGAATATCCAATGGCTCAACCCGGCCGGTTACACGC
AGGCGGTGCACATGCTGTGCGGCGACCATCTGCGTGCTTATGCGCCGCGCGACAGCCTGGGCGACGTGCCGGCAACGGTC
TACTGCGGCGCTGAAGACGTGGTCACCACGCCTGACCACAGCCGCGAACTGGCCTGGAATTTGAATTTGCCGTTCCATTT
GATCGACAATGCGGGCCACGCCTGCTACATCGAGCAACCGGGAGCGGTAGCAGCAGCCATACGTCACCAACTCAGTGGTC
ACCTTTATAAACTTTCCTAA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 31120.66 Da        Isoelectric Point: 5.7034

>AT79697 WP_094561917.1 NZ_CP022736:21018-21851 [Herbaspirillum sp. meg3]
MNKPVLPEDESQEKYLVPGLERGLRLLCEFSRQDKTLSAPELARRLDVPRSTVFRLLTTLERMGFVERNDGGRDYRLGMA
VLRLGFEYLASLELTEIGRPLLDRLRDEIGYSCNLVVRDGRSIVYVAKSVTQTAFASHVNVGTRLPAHATVLGRVLLEDL
TLAELRDLYPEEHLEVFSSNTPKTVVELFDMVQNDKMRGYVLQEGFFETSISTIAAPVRDHSGKVVAAMGATIPSPHIDT
DQLDQIVLKVRDTAGELSRLLDHAPEKSGKVVNMWRE

Download         Length: 834 bp

>AT79697 NZ_CP022736:21018-21851 [Herbaspirillum sp. meg3]
ATGAACAAACCTGTGCTGCCAGAAGACGAATCGCAAGAGAAGTACCTCGTACCAGGCCTGGAACGCGGCCTGCGCCTGCT
GTGTGAATTCAGCCGTCAGGACAAGACCCTGTCGGCGCCGGAACTGGCGCGCCGTCTCGACGTGCCGCGCTCCACCGTGT
TCCGCCTGCTGACCACGCTCGAACGCATGGGCTTTGTCGAACGCAACGACGGCGGCCGCGACTACCGCCTCGGCATGGCC
GTGCTGCGTCTCGGCTTTGAATACCTGGCCTCGCTGGAACTGACTGAAATCGGCCGTCCGTTGCTGGATCGCCTGCGCGA
TGAAATCGGCTACTCCTGCAACCTGGTCGTGCGCGATGGCCGCTCGATTGTTTATGTCGCCAAATCGGTTACGCAAACCG
CCTTCGCCAGCCACGTCAACGTCGGTACCCGTCTGCCTGCACACGCTACCGTGCTCGGCCGCGTTCTGCTGGAAGACCTG
ACCCTGGCCGAACTGCGCGACCTGTATCCGGAAGAACACCTGGAAGTTTTCTCCAGCAATACACCGAAGACCGTGGTCGA
GCTGTTCGACATGGTGCAAAACGACAAGATGCGTGGTTATGTGCTGCAAGAAGGCTTCTTCGAAACCAGCATCTCCACCA
TCGCCGCACCGGTGCGCGATCACTCGGGCAAGGTGGTGGCCGCCATGGGCGCGACGATTCCATCGCCGCACATCGACACC
GACCAGCTCGACCAGATCGTGCTCAAGGTACGCGACACCGCCGGCGAACTGTCGCGTCTGCTTGACCATGCGCCTGAGAA
ATCCGGCAAGGTCGTCAACATGTGGCGGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References