Detailed information of TA system TA079651

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 37232..37892
• Replicon: chromosome
• Accession: NZ_CP022725
• Organism: Erwinia persicina strain B64

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: CI789_RS00175
• Protein ID: WP_062744287.1
• Coordinates: 37479..37892 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A354DN60
• Locus tag: CI789_RS00170
• Protein ID: WP_062744288.1
• Coordinates: 37232..37498 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CI789_RS00150	33684..34427	+	744	WP_118663257.1	SDR family oxidoreductase	-
CI789_RS00155	34532..35140	-	609	WP_062744290.1	HD domain-containing protein	-
CI789_RS00160	35350..36003	+	654	WP_118665636.1	hemolysin III family protein	-
CI789_RS00165	36019..37005	-	987	WP_118663259.1	tRNA-modifying protein YgfZ	-
CI789_RS00170	37232..37498	+	267	WP_062744288.1	FAD assembly factor SdhE	Antitoxin
CI789_RS00175	37479..37892	+	414	WP_062744287.1	hypothetical protein	Toxin
CI789_RS00180	37885..38580	+	696	WP_062744286.1	two-component system response regulator CreB	-
CI789_RS00185	38580..40004	+	1425	WP_118663261.1	two-component system sensor histidine kinase CreC	-
CI789_RS00190	40087..41448	+	1362	WP_062744284.1	cell envelope integrity protein CreD	-
CI789_RS00195	41546..42064	-	519	WP_062744283.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-130)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16162.98 Da
• Isoelectric Point: 11.8432

>T79651 WP_062744287.1 NZ_CP022725:37479-37892 [Erwinia persicina]
VVRCHCNLRLSRHAQSLSLLLHGGVMLLLLLAPWPPEASLVKVALLLLTGGECLRSCRRTRRWQGLFVLLSGRRVQWHQA
QWQMVSPPWMTRHAVRLSLRDNQGRHERLWLFADGMDNSEWRLLRQQLLSKKEWRDE

Nucleotide

• Length: 414 bp

>T79651 NZ_CP022725:37479-37892 [Erwinia persicina]
GTGGTCCGGTGCCACTGTAACCTTCGGCTTTCACGGCACGCGCAGAGCTTATCCCTGCTACTGCACGGTGGCGTGATGCT
GTTACTGTTGCTGGCACCCTGGCCTCCCGAAGCCTCGCTGGTTAAAGTTGCTCTGCTGTTGCTGACAGGGGGGGAGTGCC
TGCGCAGTTGCCGCCGCACCCGGCGCTGGCAGGGGCTTTTTGTACTGCTCAGCGGCCGTCGCGTCCAGTGGCATCAGGCA
CAGTGGCAGATGGTTTCACCGCCATGGATGACCCGTCATGCCGTGCGTCTGTCCTTACGGGACAACCAGGGGCGGCATGA
ACGGTTGTGGCTTTTTGCCGATGGTATGGATAACAGTGAGTGGCGGCTTTTGCGCCAGCAATTGCTCAGTAAAAAGGAAT
GGCGTGATGAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10580.97 Da
• Isoelectric Point: 4.5392

>AT79651 WP_062744288.1 NZ_CP022725:37232-37498 [Erwinia persicina]
MDISNKSRIHWACRRGMRELDISIMPFFEYEYDSLNDQDKQLFVRLLENDDPDLFNWLMNHGEPADDELKRMVALIQDRN
RERGPVPL

Nucleotide

• Length: 267 bp

>AT79651 NZ_CP022725:37232-37498 [Erwinia persicina]
ATGGATATTTCAAACAAATCACGAATTCACTGGGCATGCCGTCGCGGTATGCGTGAGCTGGATATCTCCATCATGCCGTT
TTTTGAGTATGAATATGACTCGCTCAACGATCAGGATAAACAACTTTTCGTTCGCCTGCTGGAGAATGATGATCCCGATC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCCGATGACGAGTTAAAGCGCATGGTCGCCCTGATCCAGGACCGAAAC
AGAGAACGTGGTCCGGTGCCACTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A354DN60