Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 815369..815846 Replicon chromosome
Accession NZ_CP022720
Organism Staphylococcus aureus strain 135

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CGP86_RS04050 Protein ID WP_000052076.1
Coordinates 815369..815557 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGP86_RS04055 Protein ID WP_001059690.1
Coordinates 815586..815846 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP86_RS04020 811410..811880 + 471 WP_000824467.1 hypothetical protein -
CGP86_RS04025 812221..812907 + 687 WP_001641381.1 thermonuclease family protein -
CGP86_RS04030 813264..813464 + 201 WP_001059082.1 cold-shock protein -
CGP86_RS04035 813960..814178 - 219 WP_000005886.1 hypothetical protein -
CGP86_RS04040 814240..814524 - 285 WP_001004401.1 hypothetical protein -
CGP86_RS04045 814612..815181 - 570 WP_001106654.1 hypothetical protein -
CGP86_RS04050 815369..815557 - 189 WP_000052076.1 hypothetical protein Toxin
CGP86_RS04055 815586..815846 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGP86_RS04060 816187..816390 + 204 WP_000145164.1 sterile alpha motif-like domain-containing protein -
CGP86_RS04065 816387..816623 - 237 WP_000368687.1 hypothetical protein -
CGP86_RS04070 816848..817429 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CGP86_RS04075 817502..818119 - 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
CGP86_RS04080 818207..819853 - 1647 WP_000277718.1 IS1182 family transposase -
CGP86_RS04085 820193..820687 - 495 WP_000569884.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 818207..819853 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-73)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T79641 WP_000052076.1 NZ_CP022720:c815557-815369 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T79641 NZ_CP022720:c815557-815369 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT79641 WP_001059690.1 NZ_CP022720:c815846-815586 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT79641 NZ_CP022720:c815846-815586 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References