Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2161771..2162285 Replicon chromosome
Accession NZ_CP022717
Organism Staphylococcus aureus strain 27

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag CGP83_RS11140 Protein ID WP_000581792.1
Coordinates 2161771..2161980 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag CGP83_RS11145 Protein ID WP_000138932.1
Coordinates 2161992..2162285 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP83_RS11120 2157279..2158637 - 1359 WP_000611461.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
CGP83_RS11125 2158652..2159722 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
CGP83_RS11130 2160040..2161242 + 1203 WP_001109939.1 rod shape-determining protein RodA -
CGP83_RS11135 2161506..2161643 - 138 WP_000828354.1 hypothetical protein -
CGP83_RS11140 2161771..2161980 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
CGP83_RS11145 2161992..2162285 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
CGP83_RS11150 2162451..2163935 + 1485 WP_000571551.1 cardiolipin synthase -
CGP83_RS11155 2163963..2164610 + 648 WP_001187620.1 HD domain-containing protein -
CGP83_RS11170 2165241..2166113 - 873 WP_000725802.1 membrane protein insertase YidC -
CGP83_RS11175 2166199..2166840 - 642 WP_000483158.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T79624 WP_000581792.1 NZ_CP022717:c2161980-2161771 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T79624 NZ_CP022717:c2161980-2161771 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACGCCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT79624 WP_000138932.1 NZ_CP022717:c2162285-2161992 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT79624 NZ_CP022717:c2162285-2161992 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAAGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References