Detailed information of TA system TA079618

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 849203..849680
• Replicon: chromosome
• Accession: NZ_CP022717
• Organism: Staphylococcus aureus strain 27

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: -
• Locus tag: CGP83_RS04265
• Protein ID: WP_115288365.1
• Coordinates: 849203..849391 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: CGP83_RS04270
• Protein ID: WP_001059690.1
• Coordinates: 849420..849680 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP83_RS04235	845231..845713	+	483	WP_000824492.1	hypothetical protein	-
CGP83_RS04240	846054..846740	+	687	WP_000141556.1	thermonuclease family protein	-
CGP83_RS04245	847097..847297	+	201	WP_001059082.1	cold-shock protein	-
CGP83_RS04250	847794..848012	-	219	WP_000005883.1	hypothetical protein	-
CGP83_RS04255	848074..848358	-	285	WP_001004397.1	hypothetical protein	-
CGP83_RS04260	848446..849015	-	570	WP_001106648.1	hypothetical protein	-
CGP83_RS04265	849203..849391	-	189	WP_115288365.1	hypothetical protein	Toxin
CGP83_RS04270	849420..849680	-	261	WP_001059690.1	hypothetical protein	Antitoxin
CGP83_RS04275	850021..850224	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
CGP83_RS04280	850221..850457	-	237	WP_000368687.1	hypothetical protein	-
CGP83_RS04285	850682..851263	+	582	WP_001140691.1	phosphoglycerate mutase family protein	-
CGP83_RS04290	851336..851953	-	618	WP_047213256.1	LysE/ArgO family amino acid transporter	-
CGP83_RS04295	852110..852604	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
CGP83_RS04300	853003..853425	-	423	WP_031927537.1	organic hydroperoxide resistance protein	-
CGP83_RS04305	853573..854289	+	717	WP_031927536.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-74)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7128.75 Da
• Isoelectric Point: 9.6276

>T79618 WP_115288365.1 NZ_CP022717:c849391-849203 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKNTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T79618 NZ_CP022717:c849391-849203 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAATACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT79618 WP_001059690.1 NZ_CP022717:c849680-849420 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT79618 NZ_CP022717:c849680-849420 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VN56