Detailed information of TA system TA079610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 307886..308394
• Replicon: chromosome
• Accession: NZ_CP022715
• Organism: Actinobacillus pleuropneumoniae strain KL 16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0BQK9
• Locus tag: CHY23_RS01490
• Protein ID: WP_005605064.1
• Coordinates: 308134..308394 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0BQK8
• Locus tag: CHY23_RS01485
• Protein ID: WP_005598318.1
• Coordinates: 307886..308137 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHY23_RS01445	303423..303971	-	549	WP_117374039.1	type IV pilus biogenesis/stability protein PilW	-
CHY23_RS01450	304025..305206	-	1182	WP_005598300.1	bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN	-
CHY23_RS01475	306110..307549	+	1440	WP_005598316.1	glutamate--tRNA ligase	-
CHY23_RS01485	307886..308137	+	252	WP_005598318.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
CHY23_RS01490	308134..308394	+	261	WP_005605064.1	Txe/YoeB family addiction module toxin	Toxin
CHY23_RS01495	308553..308720	-	168	WP_005598320.1	Trm112 family protein	-
CHY23_RS01500	308722..309702	-	981	WP_005598322.1	tetraacyldisaccharide 4'-kinase	-
CHY23_RS01505	309796..311055	-	1260	WP_005598324.1	ATP-dependent protease ATP-binding subunit ClpX	-
CHY23_RS01510	311055..311645	-	591	WP_005598326.1	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	-
CHY23_RS01515	311767..312159	+	393	WP_005620423.1	SufE family protein	-
CHY23_RS01530	312518..313291	-	774	WP_005598329.1	DNA polymerase III subunit epsilon	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10423.99 Da
• Isoelectric Point: 8.0109

>T79610 WP_005605064.1 NZ_CP022715:308134-308394 [Actinobacillus pleuropneumoniae]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Nucleotide

• Length: 261 bp

>T79610 NZ_CP022715:308134-308394 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9362.66 Da
• Isoelectric Point: 4.5659

>AT79610 WP_005598318.1 NZ_CP022715:307886-308137 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE

Nucleotide

• Length: 252 bp

>AT79610 NZ_CP022715:307886-308137 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACGATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATTGTTCACTTGAAGAAACCGCCTATT
TGATGCGTTCACCCACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAG
CTAATCGAATGA

Structures

Toxin

• AlphaFold DB: B0BQK9

Antitoxin

• AlphaFold DB: B0BQK8