Detailed information of TA system TA079607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3354294..3354929
• Replicon: chromosome
• Accession: NZ_CP022699
• Organism: Acetobacter tropicalis strain BDGP1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CIW82_RS15370
• Protein ID: WP_014106242.1
• Coordinates: 3354294..3354704 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G2I1D7
• Locus tag: CIW82_RS15375
• Protein ID: WP_010511771.1
• Coordinates: 3354705..3354929 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIW82_RS15355	3349895..3352080	-	2186	Protein_2963	ATP-dependent RecD-like DNA helicase	-
CIW82_RS15360	3352322..3352510	+	189	WP_086896824.1	hypothetical protein	-
CIW82_RS15365	3352524..3354233	+	1710	WP_086896825.1	recombinase family protein	-
CIW82_RS15370	3354294..3354704	-	411	WP_014106242.1	tRNA(fMet)-specific endonuclease VapC	Toxin
CIW82_RS15375	3354705..3354929	-	225	WP_010511771.1	hypothetical protein	Antitoxin
CIW82_RS15380	3355109..3355528	+	420	WP_052051562.1	hypothetical protein	-
CIW82_RS15385	3355754..3356650	-	897	WP_014106240.1	NAD-dependent epimerase/dehydratase family protein	-
CIW82_RS15390	3356700..3357356	-	657	WP_052051561.1	alpha-ketoglutarate-dependent dioxygenase AlkB	-
CIW82_RS15395	3357550..3358659	-	1110	WP_014106238.1	NADH:flavin oxidoreductase/NADH oxidase	-
CIW82_RS15400	3358855..3359742	+	888	WP_014106237.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3182738..3439085	256347

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (9-55)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15558.79 Da
• Isoelectric Point: 6.4680

>T79607 WP_014106242.1 NZ_CP022699:c3354704-3354294 [Acetobacter tropicalis]
MLRYLLDTNLCIRVLRDRPQGLRPRFNSCAEELCISDVVLYELLYGAERSSDPVRTRREVERFAARLAVLPFDSEAAAHT
ADIRAELERNGRIIGPYDLMIAGHARSRGLIVVTGNLREFQRVEGLRTEDWLTDTV

Nucleotide

• Length: 411 bp

>T79607 NZ_CP022699:c3354704-3354294 [Acetobacter tropicalis]
ATGCTGCGTTATCTGCTGGATACGAACCTCTGTATCCGGGTATTGCGGGATCGACCACAAGGGCTGCGTCCGAGGTTCAA
CAGCTGTGCGGAGGAACTCTGCATCTCGGACGTGGTTCTGTATGAGCTGCTTTATGGCGCAGAACGCTCGTCCGATCCCG
TGCGCACAAGGCGTGAAGTCGAGCGCTTCGCGGCAAGGCTGGCGGTCCTGCCATTCGACAGTGAAGCAGCCGCCCATACG
GCAGACATTCGGGCCGAACTTGAACGGAATGGCCGTATCATAGGTCCGTATGATCTCATGATTGCCGGGCATGCCCGGAG
CAGAGGGCTGATTGTTGTGACCGGCAATCTGCGGGAATTTCAGCGGGTGGAGGGTCTTCGAACCGAGGACTGGCTGACTG
ACACGGTCTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8217.39 Da
• Isoelectric Point: 4.9816

>AT79607 WP_010511771.1 NZ_CP022699:c3354929-3354705 [Acetobacter tropicalis]
MLTRTTLFLSNRSQAVRLPKMVAFGEQVRDVVIVSEGSRRIIAPADAAWDDFFAAPGVDLGERNQPAMQEREAL

Nucleotide

• Length: 225 bp

>AT79607 NZ_CP022699:c3354929-3354705 [Acetobacter tropicalis]
ATGCTGACCCGTACGACACTCTTTCTATCCAACCGCTCGCAGGCAGTGCGCCTGCCGAAGATGGTCGCCTTCGGGGAGCA
GGTGCGTGACGTCGTCATTGTGTCCGAAGGTTCACGACGCATCATCGCCCCCGCTGACGCAGCGTGGGATGATTTCTTTG
CGGCTCCCGGCGTGGATCTGGGGGAGCGGAACCAGCCGGCCATGCAGGAACGTGAGGCGCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A094ZE42