Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 137798..139510 Replicon chromosome
Accession NZ_CP022684
Organism Ketobacter alkanivorans strain GI5

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag Kalk_RS00610 Protein ID WP_101892372.1
Coordinates 137798..139144 (-) Length 449 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag Kalk_RS00615 Protein ID WP_101892373.1
Coordinates 139145..139510 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Kalk_RS00595 133219..135582 - 2364 WP_199767986.1 Tn3 family transposase -
Kalk_RS00600 135742..137171 - 1430 Protein_116 DUF4158 domain-containing protein -
Kalk_RS00605 137301..137762 + 462 WP_158643243.1 hypothetical protein -
Kalk_RS00610 137798..139144 - 1347 WP_101892372.1 type II toxin-antitoxin system HipA family toxin Toxin
Kalk_RS00615 139145..139510 - 366 WP_101892373.1 helix-turn-helix domain-containing protein Antitoxin
Kalk_RS00620 139573..139797 - 225 WP_101892374.1 hypothetical protein -
Kalk_RS00625 139922..140308 + 387 WP_101892375.1 hypothetical protein -
Kalk_RS00630 140321..141913 - 1593 WP_101892376.1 NAD(P)/FAD-dependent oxidoreductase -
Kalk_RS00635 141910..142878 - 969 WP_101892377.1 alpha/beta hydrolase -
Kalk_RS00640 142893..143720 - 828 WP_101892378.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - xcpR 16550..297234 280684
- flank IS/Tn - - 135891..137111 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-72)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50476.06 Da        Isoelectric Point: 5.8157

>T79520 WP_101892372.1 NZ_CP022684:c139144-137798 [Ketobacter alkanivorans]
MADTTQAVARVLLWGRQIGTLIWTNDRGYFEYDPAFQTSGIEPSPIMMPLSNRSFSFPTLNRETFKGLPGLLADSLPDKF
GNRLINQWLERQGRSPDSFSPLERLSYIGSRGMGALEFQPAIATWDETAQPIEIAELVRLANEALSAKQAMAVDLAGADA
NKKQALEKIISVGTSAGGARAKAVIEWNPDTQEVRSGQVKTDAGFGYWLLKFDGVEENRDHEVLADPKGYSLVEYAYYLM
AIACGINMTECRIFKENGRSHFMTRRFDRKDGGEKIHMQSLCGLAHYDFNQAGAYSYEQAIGVMRDLDLPKPEFEQFFRR
VVFNVVARNQDDHTKNIAFLMDKAGIWSLSPAYDITYCNGSGWTSQHQMTVNGKRNHFVTDDLLAVARHADIRPTKAKTI
IREILEEVSQWPEFAEQAGVPPHFPGHTKGPSWMELIQQDHRLEWEGL

Download         Length: 1347 bp

>T79520 NZ_CP022684:c139144-137798 [Ketobacter alkanivorans]
ATGGCAGACACTACTCAAGCGGTCGCCCGAGTGCTGTTATGGGGGCGACAAATCGGTACCTTGATTTGGACCAATGATCG
AGGCTATTTTGAATATGACCCGGCATTTCAAACATCGGGTATCGAGCCTTCCCCGATCATGATGCCATTGAGCAACCGAT
CCTTTTCCTTTCCCACACTAAACCGGGAAACCTTCAAAGGGCTGCCGGGATTGCTGGCCGACTCGTTACCGGACAAATTT
GGTAATCGACTGATCAATCAATGGTTGGAACGCCAGGGTCGTTCCCCGGACAGTTTCAGTCCTTTGGAGCGCCTCAGTTA
TATCGGTTCACGGGGCATGGGTGCTCTGGAGTTCCAACCTGCTATAGCCACCTGGGATGAAACGGCCCAACCCATCGAGA
TCGCGGAACTGGTCAGACTGGCTAATGAAGCGTTGAGTGCCAAGCAAGCCATGGCTGTGGATTTGGCCGGGGCGGATGCC
AACAAGAAGCAAGCGCTGGAAAAGATTATTTCGGTCGGGACTTCGGCCGGCGGCGCCCGCGCTAAAGCGGTGATTGAATG
GAACCCGGATACGCAGGAAGTGCGTTCCGGACAGGTGAAAACCGATGCCGGCTTTGGTTACTGGTTATTGAAGTTCGACG
GGGTGGAAGAAAACCGGGATCACGAAGTATTAGCAGATCCCAAAGGCTATAGTCTAGTGGAATACGCCTATTATCTAATG
GCCATCGCCTGTGGCATCAACATGACAGAATGCCGTATTTTTAAGGAAAACGGCCGTTCTCATTTTATGACCCGACGGTT
TGACCGTAAAGACGGTGGCGAAAAGATCCATATGCAGTCCCTCTGTGGGTTGGCGCATTATGACTTTAACCAGGCTGGCG
CCTATTCCTACGAACAAGCCATCGGTGTGATGCGGGATCTGGATCTGCCCAAGCCGGAATTTGAACAATTCTTTCGAAGG
GTTGTGTTTAACGTCGTGGCCCGCAATCAGGACGATCACACCAAGAACATTGCGTTTTTAATGGACAAAGCCGGAATCTG
GTCACTCTCCCCCGCCTATGACATTACCTATTGCAATGGCAGTGGTTGGACCAGCCAGCACCAGATGACCGTCAACGGTA
AGCGTAATCACTTTGTGACGGACGATCTATTGGCAGTGGCGCGGCATGCGGACATTCGACCAACTAAAGCAAAGACCATT
ATCCGAGAAATCCTTGAAGAGGTGAGTCAGTGGCCTGAGTTTGCTGAGCAGGCGGGAGTGCCCCCACACTTTCCCGGCCA
CACCAAGGGTCCCTCCTGGATGGAGCTGATTCAGCAGGATCATCGGTTAGAGTGGGAAGGCCTGTAG

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13537.43 Da        Isoelectric Point: 10.1413

>AT79520 WP_101892373.1 NZ_CP022684:c139510-139145 [Ketobacter alkanivorans]
MSISHLSNQKVLEWLGERFRATRLSQNITMVDLAEKAGITERTLYNLENGTKSVGLLNVVAVLRALGKLEELDQFLPAPP
PRAEALVQIEKLQAKTRQRASRSGQSTHEGSNKKPWTWGDD

Download         Length: 366 bp

>AT79520 NZ_CP022684:c139510-139145 [Ketobacter alkanivorans]
ATGTCGATATCACATCTGAGCAACCAAAAAGTCCTGGAATGGCTTGGAGAACGCTTCCGGGCGACCCGGCTCAGCCAGAA
TATCACCATGGTGGATCTGGCGGAGAAAGCCGGTATTACTGAGCGCACCCTCTATAACCTGGAAAATGGTACAAAAAGTG
TGGGGTTATTGAACGTGGTCGCCGTTCTCCGGGCGTTGGGCAAGCTAGAGGAACTGGATCAGTTTCTGCCGGCTCCTCCA
CCCCGGGCCGAGGCCCTGGTACAGATTGAAAAGTTACAGGCAAAAACCCGACAACGAGCTTCCCGTTCCGGTCAGAGTAC
ACATGAAGGAAGCAATAAAAAGCCCTGGACCTGGGGGGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References