Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2397582..2398066 Replicon chromosome
Accession NZ_CP022672
Organism Shigella sonnei strain 866

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag CH310_RS12055 Protein ID WP_014334020.1
Coordinates 2397582..2397872 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag CH310_RS12060 Protein ID WP_005142544.1
Coordinates 2397872..2398066 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH310_RS12020 (2392761) 2392761..2393857 - 1097 Protein_2316 molybdopterin dinucleotide binding domain-containing protein -
CH310_RS12025 (2393915) 2393915..2394612 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
CH310_RS12030 (2394606) 2394606..2395394 - 789 Protein_2318 Rha family transcriptional regulator -
CH310_RS12040 (2395927) 2395927..2396624 + 698 WP_233395158.1 IS1-like element IS1A family transposase -
CH310_RS12045 (2396772) 2396772..2397137 - 366 WP_024174355.1 hypothetical protein -
CH310_RS12050 (2397149) 2397149..2397301 - 153 WP_000379558.1 DUF1391 family protein -
CH310_RS12055 (2397582) 2397582..2397872 - 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH310_RS12060 (2397872) 2397872..2398066 - 195 WP_005142544.1 hypothetical protein Antitoxin
CH310_RS12065 (2398086) 2398086..2398523 - 438 WP_001085710.1 helix-turn-helix domain-containing protein -
CH310_RS12070 (2398698) 2398698..2398961 + 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
CH310_RS12075 (2398958) 2398958..2399383 + 426 WP_000693826.1 toxin YdaT family protein -
CH310_RS12080 (2399455) 2399455..2400519 + 1065 WP_001262380.1 hypothetical protein -
CH310_RS12085 (2400526) 2400526..2401272 + 747 WP_000788740.1 ATP-binding protein -
CH310_RS12090 (2401294) 2401294..2402019 + 726 WP_000450631.1 DUF1627 domain-containing protein -
CH310_RS12095 (2402035) 2402035..2402457 + 423 WP_001151171.1 DUF977 family protein -
CH310_RS12100 (2402515) 2402515..2402871 + 357 WP_005140877.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2394606..2424537 29931


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T79498 WP_014334020.1 NZ_CP022672:c2397872-2397582 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T79498 NZ_CP022672:c2397872-2397582 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT79498 WP_005142544.1 NZ_CP022672:c2398066-2397872 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT79498 NZ_CP022672:c2398066-2397872 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References