Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1205199..1205817 Replicon chromosome
Accession NZ_CP022672
Organism Shigella sonnei strain 866

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CH310_RS05875 Protein ID WP_001291435.1
Coordinates 1205199..1205417 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag CH310_RS05880 Protein ID WP_000344804.1
Coordinates 1205443..1205817 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH310_RS05840 (1200491) 1200491..1201063 + 573 WP_000779812.1 YbaY family lipoprotein -
CH310_RS05845 (1201094) 1201094..1201405 - 312 WP_000409911.1 MGMT family protein -
CH310_RS05855 (1201784) 1201784..1202137 + 354 WP_000878140.1 DUF1428 domain-containing protein -
CH310_RS05860 (1202179) 1202179..1203727 - 1549 Protein_1131 cyclic-guanylate-specific phosphodiesterase PdeB -
CH310_RS05865 (1203891) 1203891..1204361 - 471 WP_000136192.1 YlaC family protein -
CH310_RS05870 (1204477) 1204477..1205028 - 552 WP_000102564.1 maltose O-acetyltransferase -
CH310_RS05875 (1205199) 1205199..1205417 - 219 WP_001291435.1 HHA domain-containing protein Toxin
CH310_RS05880 (1205443) 1205443..1205817 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
CH310_RS05885 (1206363) 1206363..1209512 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
CH310_RS05890 (1209535) 1209535..1210728 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T79489 WP_001291435.1 NZ_CP022672:c1205417-1205199 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T79489 NZ_CP022672:c1205417-1205199 [Shigella sonnei]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT79489 WP_000344804.1 NZ_CP022672:c1205817-1205443 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT79489 NZ_CP022672:c1205817-1205443 [Shigella sonnei]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGAGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References