Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 881212..882014 Replicon plasmid pPR1
Accession NZ_CP022666
Organism Rhizobium leguminosarum bv. viciae strain BIHB 1217

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A444IGY5
Locus tag CHR56_RS29630 Protein ID WP_018245608.1
Coordinates 881212..881739 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A7Y3SJF5
Locus tag CHR56_RS29635 Protein ID WP_018245607.1
Coordinates 881736..882014 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR56_RS29615 876510..877634 - 1125 WP_018245611.1 DNA repair exonuclease -
CHR56_RS29620 877924..879315 - 1392 WP_026188694.1 aldehyde dehydrogenase family protein -
CHR56_RS29625 879317..880963 - 1647 WP_018245609.1 acetolactate synthase large subunit -
CHR56_RS29630 881212..881739 - 528 WP_018245608.1 GNAT family N-acetyltransferase Toxin
CHR56_RS29635 881736..882014 - 279 WP_018245607.1 DUF1778 domain-containing protein Antitoxin
CHR56_RS29640 882169..883047 - 879 WP_026188693.1 hypothetical protein -
CHR56_RS29645 883371..885485 - 2115 WP_018245605.1 carboxy terminal-processing peptidase -
CHR56_RS29650 885633..886112 - 480 WP_020493431.1 MEKHLA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..1169137 1169137


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(12-87)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 18780.78 Da        Isoelectric Point: 9.5510

>T79481 WP_018245608.1 NZ_CP022666:c881739-881212 [Rhizobium leguminosarum bv. viciae]
VTLPVWHEEPIAKSHDRASFDCGDAAMNEFIRRFARQSHEQNAAKTFCAIDKAHPDRILGFYTVAPSAVTHEAVPPKMTR
GLARHEVAGFKLARLATDIKVAGKGLGGQLIAAAALRCLRLASEGGGILLIIDAKSERAAHWYASYGAEPLQGKPLTLVM
PLATFAADLKAKGLL

Download         Length: 528 bp

>T79481 NZ_CP022666:c881739-881212 [Rhizobium leguminosarum bv. viciae]
GTGACCCTCCCCGTCTGGCATGAAGAGCCGATCGCTAAGTCGCATGATCGGGCCTCATTCGATTGCGGTGATGCGGCAAT
GAACGAGTTCATTCGGCGCTTCGCCCGGCAGAGCCATGAGCAGAATGCGGCGAAAACCTTCTGCGCTATCGACAAGGCCC
ACCCTGATCGCATCCTCGGATTCTACACAGTCGCGCCCTCTGCCGTTACGCATGAGGCCGTGCCTCCGAAGATGACGAGA
GGCCTCGCACGCCATGAAGTCGCAGGCTTCAAGCTCGCGCGCTTGGCAACCGACATAAAGGTGGCGGGAAAAGGTTTAGG
CGGTCAGCTCATCGCTGCTGCAGCGCTCCGTTGCCTGCGGCTCGCCAGCGAGGGCGGCGGGATCCTGCTAATCATCGATG
CCAAGAGCGAGCGCGCCGCCCATTGGTATGCCAGCTACGGCGCCGAACCGCTGCAAGGGAAACCGCTCACCCTCGTTATG
CCGCTTGCCACCTTCGCCGCCGACCTGAAGGCCAAGGGGCTCCTGTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10222.91 Da        Isoelectric Point: 9.8602

>AT79481 WP_018245607.1 NZ_CP022666:c882014-881736 [Rhizobium leguminosarum bv. viciae]
MPRTADNKSERYQLRIPPKQKAMIARAAALSNKDMADFILDKIVPEAEAVIQAAEVETVSSRDFIRILDLLERPPKPNAR
LRAAISALPDAL

Download         Length: 279 bp

>AT79481 NZ_CP022666:c882014-881736 [Rhizobium leguminosarum bv. viciae]
ATGCCGAGAACCGCGGACAATAAATCCGAACGCTACCAGCTGCGCATCCCGCCAAAGCAGAAGGCAATGATCGCGCGCGC
AGCTGCCCTTTCGAACAAGGATATGGCCGATTTCATTCTCGATAAGATAGTACCTGAAGCCGAAGCCGTCATCCAGGCTG
CTGAAGTTGAGACCGTTTCGAGCCGCGATTTCATCCGCATCCTCGACCTGCTTGAACGCCCGCCCAAACCAAACGCGAGA
CTACGCGCCGCGATCTCTGCTCTACCGGATGCCTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444IGY5

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3SJF5

References