Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 110095..110620 Replicon plasmid pRM11065-1
Accession NZ_CP022661
Organism Salmonella enterica subsp. enterica strain RM11065

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag CGA24_RS00605 Protein ID WP_097361885.1
Coordinates 110095..110400 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag CGA24_RS00610 Protein ID WP_097361886.1
Coordinates 110402..110620 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGA24_RS00580 105701..106699 + 999 WP_097361880.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
CGA24_RS00585 106738..108288 + 1551 WP_097361881.1 gluconate permease -
CGA24_RS00590 108502..109284 - 783 WP_097361882.1 site-specific integrase -
CGA24_RS00595 109281..109715 - 435 WP_097361883.1 hypothetical protein -
CGA24_RS00600 109812..110093 - 282 WP_097361884.1 cytoplasmic protein -
CGA24_RS00605 110095..110400 - 306 WP_097361885.1 type II toxin-antitoxin system toxin CcdB Toxin
CGA24_RS00610 110402..110620 - 219 WP_097361886.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
CGA24_RS00615 111186..111800 + 615 WP_097361887.1 DNA-binding protein -
CGA24_RS00620 112157..112384 - 228 Protein_119 integrase -
CGA24_RS00625 112588..112812 + 225 Protein_120 antitermination protein -
CGA24_RS00630 113521..114086 + 566 Protein_121 transposase -
CGA24_RS00635 114165..114569 - 405 WP_097361888.1 transposase -
CGA24_RS00645 114949..115242 - 294 WP_198404649.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..143770 143770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-87)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-93)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T79452 WP_097361885.1 NZ_CP022661:c110400-110095 [Salmonella enterica subsp. enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T79452 NZ_CP022661:c110400-110095 [Salmonella enterica subsp. enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT79452 WP_097361886.1 NZ_CP022661:c110620-110402 [Salmonella enterica subsp. enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT79452 NZ_CP022661:c110620-110402 [Salmonella enterica subsp. enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References