Detailed information of TA system TA079450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 223544..224100
• Replicon: plasmid pRM11060-2
• Accession: NZ_CP022660
• Organism: Salmonella enterica subsp. enterica strain RM11060

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A3R0U7A1
• Locus tag: CGA23_RS26715
• Protein ID: WP_000404186.1
• Coordinates: 223825..224100 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CGA23_RS26710
• Protein ID: WP_065314520.1
• Coordinates: 223544..223825 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGA23_RS26705	222721..223461	+	741	WP_057395086.1	conjugal transfer pilus acetylase TraX	-
CGA23_RS26710	223544..223825	+	282	WP_065314520.1	ribbon-helix-helix protein, CopG family	Antitoxin
CGA23_RS26715	223825..224100	+	276	WP_000404186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CGA23_RS26720	224138..224701	+	564	WP_057395085.1	fertility inhibition protein FinO	-
CGA23_RS26730	225020..225280	+	261	WP_097361646.1	hypothetical protein	-
CGA23_RS26740	225834..226178	+	345	WP_057395081.1	hypothetical protein	-
CGA23_RS26745	226210..226533	+	324	WP_023223027.1	PerC family transcriptional regulator	-
CGA23_RS26750	226527..226898	+	372	Protein_249	hypothetical protein	-
CGA23_RS26755	227087..227293	+	207	WP_023223029.1	hemolysin expression modulator Hha	-
CGA23_RS27365	227450..227764	-	315	WP_157762365.1	hypothetical protein	-
CGA23_RS26765	228207..228761	+	555	WP_079953196.1	thioredoxin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..290957	290957

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11810.03 Da
• Isoelectric Point: 12.7590

>T79450 WP_000404186.1 NZ_CP022660:223825-224100 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKK

Nucleotide

• Length: 276 bp

>T79450 NZ_CP022660:223825-224100 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>AT79450 WP_065314520.1 NZ_CP022660:223544-223825 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>AT79450 NZ_CP022660:223544-223825 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A3R0U7A1